LEVAMIZOLE Injection 10%
Treatment of cattle, sheep, goats, pigs for diseases caused by
in cattle, sheep and goats: by gastrointestinal nematodes (adults and larval forms): Haemonchus spp., Ostertagia spp., Cooperia spp., Trichostrongylus spp., Nematodirus spp., Dunostomum spp., Oesophagostomum spp .; and pulmonary nematodes: Dictyocaulus spp .;
in pigs: gastrointestinal nematodes: Ascaris suum, Strongyloides ransomi, Oesophagostomum spp., pulmonary nematodes: Metastrongylus spp.
Levamisole hydrochloride, a left-turning isomer, belongs to the imidazole group and is a biologically active derivative of tetramisole. Inhibiting the enzyme acetylcholinesterase blocks the formation of ATP, affects the neuromuscular system of the parasite, causes contraction of its muscles and paralysis, which leads to the death of parasites in the first 12-24 hours after administration, In the liver of animals levamisole, is transformed into oxy-mercapto et imidazolidine, which has a positive effect on the immune system of mammals and birds.
Levamisole the anthelmintic effect is due to the blockade of succinate dehydrogenase, the suppression of the fumarate recovery process and, as a consequence, the violation of energy metabolism in helminths. Causes depolarization of the helminth muscle cell membranes. Paralyzed nematodes are removed from the body by normal intestinal peristalsis within 24 hours after ingestion. It is especially active against Ascaris lumbricoides, Necator Americanus and Ancylostoma duodenale.