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Praziquantel anthelmintic dewormer.
Praziquantel induces rapid muscle contracture in schistosomes through a specific effect on the permeability of the cell membrane. In addition, it induces vacuolization and disintegration of the schistosomal tegument. After oral administration, praziquantel is rapidly absorbed (80%), undergoes the effect of the first pass through the liver, metabolized and excreted by the kidneys. Cmax in serum is reached within 1-3 hours after administration.
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