Fenbendazole, has a wide spectrum of anthelmintic action, is active against nematodes, trematodes and cestodes parasitizing in animals. Fenbendazole is rapidly absorbed in the gastrointestinal tract. The mechanism of action of fenbendazole is a metabolic disorder, inhibition of fumarate reductase activity and the synthesis of ATP parasite, which leads to the death of helminths. According to the degree of toxic effects on the body, it belongs to low-hazard substances, in the recommended doses it does not have a mutagenic, carcinogenic and locally irritating effect. It is excreted mainly with feces.
Application: Dehelmintization of animals during dictiocauliasis, hematosis, ostertagia, trichostrongiasis, nematodirosis, cooperiosis, esophagostomiasis, moniesiosis and fascioliasis.
Sodium chloride is involved in water-salt metabolism, maintains and regulates osmotic pressure, has detoxification, rehydration effect, replenishes sodium deficiency in various pathological conditions of the body, temporarily increases the volume of fluid circulating through the vessels.
Sodium ions penetrate the cell membrane through various transport mechanisms, in particular the sodium-potassium pump (Na-K-ATPase). Sodium contributes to the transmission of signals in neurons, electrophysiological processes of the heart, metabolic processes in the kidneys. It is excreted from the body after renal reabsorption in the urine, a small amount in the feces and sweat.
Indications
Treatment of animals with significant losses of organic fluid (dehydration) - intoxication, diarrhea, burn disease, toxic dyspepsia, decreased blood pressure, shock, after surgery.
For washing wounds, mouth, nose, mucous membranes of the eyes, as a solvent for veterinary and biological products.
APPLICATION
Method of administration and dosage
Before use, the drug is heated to the body temperature of the animal and injected intravenously, intramuscularly, or subcutaneously in the following doses per animal:
It is indicated for the treatment of diseases associated with disorders of the central nervous system (inhibition and excitation), violation of the autonomic nervous system, severe acute infectious diseases, various forms of cardiovascular disease, the fall of blood pressure, significant blood loss. Glucose solutions are indicated in case of poisoning, intoxication by narcotic drugs, mercury, arsenic, strychnine, sodium nitrite, and other substances; pulmonary edema, liver diseases (hepatitis and cirrhosis), lack of diuresis; acetonemia, postpartum hemoglobinuria in cows, ketonuria and toxemia of dairy cows, sheep ketonuria; weak uterine contractility, maternity paresis; as a hemostatic agent while gastrointestinal, lung and other internal bleeding, hemorrhagic diathesis. Some drugs to reduce toxicity or extension of their validity are dissolved in solutions of glucose.