Ivermectin

Kloziver (closantel,ivermectin) injectable

Kloziver is a combination drug, comprising closantel and ivermectin. Closantel is a salicylamide’s derivative, providing antiparasitic action. Closantel’s mode of action centers around inhibition of oxidative phosphorylation. Specific action centers around ATP stimulation, leading to stopping of a phosphorylation process and electrons’ transfer, changing suchwise parasite’s energy metabolism. This leads to its death. Ivermectin refers to compounds, which are produced by Streptomices avermitis. Ivermectin’s mode of action on parasite’s body centers around secretion stimulation of GABA (gamma-amino-butyric acid), which binds to special receptors of nerve endings, blocking nerve impulses and causing paralysis and death of a parasite.