Ketofur 200 (ketoprofen – 150 + ceftiofur hydrochloride – 50) (Ketofen analog)
Pig treatment for respiratory diseases
Vials closed with rubber stoppers for aluminum running in 100 ml
The oily suspension from yellow to brownish-yellow in color, with a slight smell of constituents, exfoliates during storage.
1 ml of the drug contains active ingredients:
ceftiofur hydrochloride – 50.0 mg;
ketoprofen – 150.0 mg.
ATC vet classification code QJ01- antibacterial veterinary preparations for systemic use. QJ0DD99 – ceftiofur, combinations.
Ceftiofur belongs to the group of third-generation cephalosporins. It is active against gram-positive and gram-negative bacteria, including strains producing beta-lactamases, and some anaerobic bacteria: Escherichia coli, Pasteurella haemolytica, Pasteurella multocida, Haemophilus Somnus, Actinobacillus pleuropneumoniae, Haemophilus parasuisocismellis, Salisuochemella parasuisis, Salisemis paraphuisis, Salis hemophilis paraleguis, Salmonis parasiusis, Pleisuoccephis Vulgaris, , Staphylococcus spp., Actynomyces pyogenes, Salmonella typhimurium, Streptococcus agalactiae, S. dysgalactiae, S. bovis, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Poromomeromomium fungomomerumoma bomomerumomacteromumum ) The mechanism of action of the antibiotic is to suppress the synthesis of the bacterial cell wall.
Ketoprofen – NSAIDs based on propionic acid. It has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase. In addition, ketoprofen inhibits lipoxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, and causes a significant inhibition of neutrophil activity. Ketoprofen is a dual inhibitor of inflammation, blocking the action of cyclooxygenase and lipoxygenase and, thus, preventing the formation of prostaglandins and leukotrienes.
Ketoprofen is a painkiller that affects the central and peripheral nervous systems. Its effect is the direct suppression of the action of bradykinin, vasodilators and pain mediators.
After parenteral administration, ceftiofur is rapidly absorbed into the injection site and penetrates into all tissues of the animal. Its maximum plasma concentration is observed after an hour, which is maintained at a therapeutic level for up to 24 hours, depending on the type of animal.
Ceftiofur in the body is rapidly metabolized to form desfuroilceftiofur, which has activity equivalent to ceftiofur against bacteria. This active metabolite binds back to plasma proteins and accumulates in the focus of infection, while its activity does not decrease in the presence of necrotic tissues.
Withdrawal of the antibiotic occurs mainly with urine and feces.
Ketoprofen is rapidly absorbed. Binds to plasma proteins. Significant concentrations of ketoprofen were found in the synovial fluid, and its level is higher than in plasma, and the half-life is 2-3 times higher than in plasma. Ketoprofen is metabolized in the liver to minor biologically active metabolites, and 90% is excreted in the urine as glucuronide compounds.
Treatment of cows with necrobacteriosis and endometritis, as well as respiratory diseases caused by microorganisms sensitive to ceftiofur.
Once a day at a dose of 1 ml per 50 kg of animal body weight (1 mg of ceftiofur and 3 mg of ketoprofen per 1 kg of animal body weight). The course of treatment for respiratory diseases is 3-5 days, for necrobacteriosis – 3 days, for endometritis – 5 days.
Before use, the drug bottle should be shaken and heated to 36 ° C.
Slaughter of animals for meat is allowed 8 days after the last use of the drug. The withdrawal period for milk is 0 hours. Received, by the indicated time, meat is disposed or fed to unproductive animals, depending on the conclusion of the veterinarian.
Do not use in animals with acute renal failure.
Do not use in animals under 6 weeks of age.
Do not use in animals with impaired hematopoiesis, gastrointestinal ulcers, kidney, and liver diseases. Do not use in animals in a state of hypotension, hypovolemia, and dehydration.
Do not use simultaneously with other non-steroidal anti-inflammatory, diuretics, or anticoagulants, as well as with tetracyclines, chloramphenicol, macrolides, and lincosamides.
Form of packaging
Glass bottles 100 ml, 200 ml closed with a rubber plug under an aluminum cap.
Dry dark place at a temperature from 10 ° C to 25 ° C. Avoids freezing.
Expiration date – 3 years from the manufacturing date.