UpCard 3 mg, 10 tab (torasemide) Vetoquinol

International non-proprietary name: torasemide.

Dosage form: tablets for oral use.

In appearance, UpCard is a tablet from white to cream, oblong in shape with dividing notches (divisible).

Storage
UpCard contains torasemide as an active substance.

The drug is available in three versions: torasemide 0.75 mg, 3 mg and 7.5 mg. As excipients, UpCard contains lactose monohydrate, povidone, crospovidone, sodium lauryl sulfate, microcrystalline cellulose, sodium stearyl fumarate and bacon flavoring.

Pharmacological properties
UpCard belongs to the group of loop diuretics.

The mechanism of action of torasaemide is to inhibit the reabsorption of sodium and chlorine ions in the lumen of the tubules of the medullary part of the ascending knee of the Henle loop, which leads to increased excretion and reduced osmolarity of the interstitial space in the medullary layer of the kidney. from the body.

After oral administration of the drug torasemide is rapidly absorbed, enters the bloodstream, reaching a maximum concentration in less than 1 hour. Bioavailability is 90%.

Torasemide is slightly metabolized (about 7-10%) in the liver and excreted unchanged, mainly through the urinary system. The half-life is 7 hours.

According to the degree of impact on the body UpCard is a low-hazard substance

The order of application
UpCard is prescribed to dogs as a diuretic to relieve clinical signs of congestive heart failure, including edema and effusions.

UpCard is administered individually, orally, regardless of feeding regimen, at a dose of 0.1 to 0.6 mg of torasemide per 1 kg of animal weight once daily.

In most dogs, the condition can be stabilized at a dose of torasemide less than or equal to 0.3 mg / kg body weight once daily.

The dose of torasemide should be titrated to an acceptable level for the patient, taking into account renal function and electrolyte status. If the diuretic level needs to be changed, the dose may be increased or decreased within the recommended dose range in increments of OD mg / kg animal weight. Dose adjustments should be made as directed by a veterinarian.

Renal function, hydration and electrolyte balance should be monitored:

at the time of therapy;
24-48 hours after starting therapy;
24-48 hours after dose change;
in case of adverse events.
If long-term therapy is required, treatment should be continued with the minimum effective dose.

Contraindication
UpCard is contraindicated in animals with renal insufficiency, severe dehydration, hypovolemia or hypotension, as well as in case of individual hypersensitivity to the drug or its components.

Do not use UpCard concomitantly with other loop diuretics. Upcard should be used with caution when using antihypertensive drugs.

UpCard is not intended for use in productive animals.

Features of application
UpCard should be used with caution in diabetes and in dogs who have previously received high doses of another loop diuretic.

UpCard is not intended for use in animals during pregnancy and lactation, as well as breeding animals.

Skipping the next dose of the drug should be avoided, as this may reduce its therapeutic efficacy. If you miss one or more doses of the drug, the course of treatment should be resumed in the prescribed dosages and regimen. Do not inject a double dose to make up for a forgotten dose.

Overdose
In case of drug overdose, dehydration, electrolyte imbalance, renal failure, anorexia, weight loss and cardiovascular collapse may occur in animals. Carry out symptomatic treatment.

Features of action
Features of action at the first use of UpCard and at its cancellation are not established.

Side effects
The following side effects may occur with UpCard: increased renal function (creatinine and urea nitrogen) and renal failure, hemoconcentration, polyuria and / or polydipsia, electrolyte deficiency and dehydration, vomiting, diarrhea, decreased or no stool, soft text. kalu.

Depending on the severity of adverse reactions, dose adjustment, symptomatic treatment or discontinuation of the drug is possible. The decision is made by the attending veterinarian after assessing the clinical condition of the animal and the benefit-risk balance.

In case of allergic reactions in animals, the use of the drug is stopped and symptomatic treatment is prescribed.

Personal prevention measures
When working with the drug should follow the general guidelines