Baycox analog 2,5% – Solution for poultry 1 ml x 50 ampules

Description

Transparent colorless or yellowish solution.

Composition

1 ml of the drug contains the active substance – toltrazuril – 25 mg Excipients: triethanolamine, polyethylene glycol-400.

Pharmacological properties

ATS vet code: QP51A – Antiprotozoal drugs. QP51AJ01 – Toltrazuril.

Toltrazuril, which is part of the drug TOLTRACOX, belongs to the triazinetrione group. It has an eimeriocidal effect at all stages of development of pathogens, causing changes in their microstructure, which are primarily caused by edema of the endoplasmic reticulum and Golgi apparatus, abnormal changes in the perinuclear space and disorders of cell division. Toltrazuril causes a decrease in the activity of respiratory chain enzymes in parasites.

TOLTRACOX is effective against all types of Eimeria (Eimeria acervulina, E. anseris, E. brunetti, E. necatrix, E. mitis, E. adenoides, E. truncata) of poultry. TOLTRACOX is moderately toxic to birds and does not interfere with the formation of immunity to Eimeria.

After oral administration, toltrazuril is slowly absorbed in the gastrointestinal tract, reaching maximum plasma concentrations after 24 hours. The bioavailability of the drug is 70%. In the body of birds, toltrazuril is partially metabolized to form sulfoxide and sulfone derivatives.

Toltrazuril is excreted slowly (the half-life is approximately 76 hours) in unchanged form and as the main metabolite (sulfone), mainly with feces and partially with urine.

Use

Treatment of poultry (broiler chickens, replacement young chickens, turkeys, geese and ducks) for eimeria infections caused by:

in chickens (broiler chickens, replacement young chickens): E. acervulina, E. brunetti, E. tenella, E. maxima, E. necatrix, E. mitis;
in turkeys: E. adenoides, E. meleagrimitis;
in geese and ducks: E. anseris, E. nosens, E. anatis, E. danailovi, E. truncata.
Dosage

TOLTRACOX is administered orally with drinking water in the following doses (the dose is 7 mg toltrazuril / kg body weight of the bird or 0.28 ml of the drug per kg body weight per day):

1 ml per 1 l of drinking water, which is given for 2 days (48 hours);
3 ml per 1 l of drinking water, which is given every 8 hours for two days.
To ensure the correct dose, it is necessary to accurately calculate the total weight of the treated animals and the daily water consumption.

The drinking water with the medicine should be renewed every 24 hours. The solution with the drug is used as the only source of drinking water. If a precipitate appears, stir the solution before use. If necessary, the treatment course of the bird is repeated after 5 days. The solution of the drug in drinking water is used within 24 hours.

Contraindications

Do not use in animals with hypersensitivity to the active substance or any of the excipients.

Precautions

Side effects

None known.

Special precautions for use

As with any anticoccidial drugs, frequent and prolonged use of antiprotozoal drugs of the same class may lead to the development of resistance. It is important to adhere to the recommended dosage to minimise the risk of resistance.

If resistance is present, the use of another antiprotozoal agent from a different class or with a different mechanism of action should be considered.

For best results, treatment should be initiated before clinical signs of disease have spread to the entire flock.

The veterinary medicinal product is a potent solution and should not be administered undiluted.

Use during pregnancy, lactation, lay

Do not use in laying hens intended to produce eggs for human consumption.

Interaction with other medicinal products and other forms of interaction

Concomitant use of the product with antibiotics may lead to a reduction in water consumption by turkeys.

Overdose (symptoms, emergency procedures, antidotes)

A reduction in drinking water consumption may be the first sign of overdose. This is only observed after exceeding the recommended dose by more than 10 times.

Special precautions

To prevent the occurrence of eymeriosis, it is recommended to eliminate any shortcomings in poultry breeding, poultry houses should be kept clean and dry.

It is recommended to treat all animals in the pen. For best results, treatment should be started before clinical signs of the disease spread to the entire group.

Withdrawal period

Slaughter of poultry for meat is allowed 16 days after the last use of the drug. Meat obtained before this period is disposed of or fed to unproductive animals, depending on the conclusion of the veterinarian.

Special precautions for persons and staff

Persons administering TOLTRACOX to animals should observe the general rules of personal hygiene and safety precautions that apply when working with veterinary medicinal products.

People with known hypersensitivity to toltrazuril should avoid contact with the veterinary medicinal product.

TOLTRACOX is an alkaline solution. When working with the product, rubber gloves should be worn. Contact with skin and mucous membranes should be avoided. In case of direct contact with eyes or skin, rinse immediately and thoroughly with water. Smoking, eating and drinking are prohibited while using the product. In case of accidental ingestion, seek medical advice immediately (have the package leaflet or label with you). After handling the product, wash hands with warm water and soap.

Incompatibilities (main)

The simultaneous introduction of other substances into drinking water should be avoided. Do not use simultaneously with other drugs of similar action.

Release form

Glass ampoules of 1 ml in a pack.

Storage

In a dry, dark place inaccessible to children at a temperature of 5 to 25 °C. Shelf life – 3 years. After the first withdrawal from the bottle, the drug should be stored in a hermetically sealed container for no more than 3 months.

For use in veterinary medicine!