Kloziver (closantel,ivermectin) injectable
Kloziver is a combination drug, comprising closantel and ivermectin. Closantel is a salicylamideβs derivative, providing antiparasitic action. Closantelβs mode of action centers around inhibition of oxidative phosphorylation. Specific action centers around ATP stimulation, leading to stopping of a phosphorylation process and electronsβ transfer, changing suchwise parasiteβs energy metabolism. This leads to its death. Ivermectin refers to compounds, which are produced by Streptomices avermitis. Ivermectinβs mode of action on parasiteβs body centers around secretion stimulation of GABA (gamma-amino-butyric acid), which binds to special receptors of nerve endings, blocking nerve impulses and causing paralysis and death of a parasite.