Closan – Closantel
Bottles sealed with a gray rubber stopper, with an aluminum cap on top
Release Type:
Application:
Prevention and treatment of cattle and small ruminants from the following diseases
СOMPOSITION
1 ml contains: closantel – 50 mg;
PACKAGING
Glass bottles of 10, 50, 100 and 250 ml. Bottles sealed with a gray rubber stopper, with an aluminum cap on top
DESCRIPTION.
Clear thick yellow solution.
PHARMACOLOGICAL CHARACTERISTICS.
ATCvet QP52A, anti-distomiasis, anti-nematodosis and anti-cestodiasis veterinary drugs (QP52AG09, closantel).
The active ingredient of the drug – closantel, antiparasitic agent, structurally derived salicylanilide that has a long effect on endo- and ectoparasites.
Closantel blocks the phosphorylation process (formation of ATP) in the body of parasites through interference in the process of transporting electrons, changing energy metabolism, resulting in the death of parasites.
Closantel has a wide range of actions, effective in the treatment of parasitic diseases of cattle and small ruminants caused by nematodes, trematodes, and arthropods.
Closantel is rapidly absorbed after oral or intramuscular administration. The maximum concentration in the blood of sheep is reached after 8-24 hours after administration, the blood of cattle – 24-48 hours.
The half-decomposition is approximately 12-15 days. Most part of the used closantel is concentrated in the lungs and kidneys, and the main way of its metabolism is renewable deionization. APPLICATION.
Prevention and treatment of cattle and small ruminants from the following diseases:
cattle: – fasciolosis (Fasciola hepatica, mature and late larval forms); – nematodes (adult and larval forms Bunostomum spp., Haemonchus сontortus, Haemonchus placei, and Oesophagostomum radiatum); – hypodermis caused by the larvae of subcutaneous gadfly Hypoderma spp.;
sheep, goats: – fasciolosis (Fasciola hepatica, mature and late larval forms); – nematodes (adult and larval forms Bunostomum spp., Haemonchus сontortus, Haemonchus placei, and Oesophagostomum radiatum, Chabertia ovina); – oestrosis (Oestrosis ovis).
DOSAGE.
The drug should be given only by subcutaneous once at the doses given in the table. It is recommended to inject the dose-volume in a few different spots.
CONTRAINDICATIONS.
Do not use it with other antiparasitic chlorine-organic drugs. Do not use for dairy and pregnant cattle in the last trimester of pregnancy.
PRECAUTIONS.
Slaughter of animals for meat is permitted in 28 days, using milk for human nutrition – 14 days after the drug usage. Slight inflammation in the injection site is possible, but it disappears independently in two-three days after injection. Some breeds of cattle (Charolais and its hybrids) are particularly sensitive to the drug, approximately 2% of the animals had anaphylactic reactions after the injection.
STORAGE.
Store in a cool, dry, dark place at the temperature from 5 to 25°C.
Expiration date – 2 years from the date of manufacture.
|
Type animals |
Diseases |
The dose by the active substance |
Dose |
| Cattle | fasciolosisnematodosis hypodermis | 2,5 mg closantel per kg of body weight2,5 mg closantel per kg of body weight 5 mg closantel per kg of body weight | 0,5 ml/10 kg of body weight0,5 ml/10 kg of body weight 1 ml/10 kg of body weight |
| Sheep, goats | fasciolosisnematodosis, oestrosis | 5 mg closantel per kg of body weight2,5 mg closantel per kg of body weight | 1 ml/10 kg of body weight0,5 ml/10 kg of body weight |
