Levamisole hydrochloride solution for injection, 100 ml
1 ml of the drug contains:
levamisole hydrochloride – 80 mg
The liquid is colorless, transparent, without mechanical inclusions, with a faint specific odor.
Levamisole hydrochloride is a synthetic compound from the group of imidazothiales. Inhibits the enzyme of basic fumarate reductase metabolism and ATP formation, paralyzes nerve nodes, causes paralysis and death of nematodes in the first 12-24 hours after administration.
Quickly absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is observed in 1,5-2 hours. Biologically transformed in the liver with the formation of inactive metabolites. The half-life is 3-4 hours, metabolites – about 16 hours. Excreted mainly by the kidneys (more than 95%) in the form of inactive metabolites and gastrointestinal tract (approximately 5%) and less than 0.2% unchanged.
The drug has a complex effect on the immune system, especially in immunosuppressive conditions: increases the production of antibodies to various antigens, activates T-lymphocytes and stimulates their proliferation, increases the function of monocytes, macrophages and neutrophils (chemotaxis, phagocytosis, adhesion).
Treatment of animals and poultry in diseases caused by:
- cattle, sheep, goats – nematodes of the gastrointestinal tract and lungs Trichostrongylus columbriformis, T. axei, Ostertagia circumcincta, Haemonchus contortus, Nematodirus spathiger, Oesophagostomum venulosum, O. solumbianum, O. radiatum, T. bucephaumum globulosa, Strongyloides papillosus, Dictyocaulus filaria, D. viviparus, Muellerius capillaris, Protostrongylus kochi, Neoascaris vitulorum, etc .;
- pigs – нематодами Brassica campestris, Trichuris suis, Oesophagostoraum dentate, Metastrongylus elongated M. pudendotectus, M. Salmi, M. pulmonary M. tschiauricus, Ollulanus tricuspis O. his trongyloides ransomi;
- dogs — Toxocara canis, T. cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum;
- bird (chickens, geese, turkeys, pigeons) – Ascaridia galli, Heterakis gallinarum, Capillaria spp., Trichostrongylus spp.
Method of application and dosage
Doses and methods of administration of the drug for different species of animals are listed in the table.
|Animal species||Dose, ml / 10 kg of body weight||Method of administration||Application|
|Cattle||one||p / sh (lower middle of the neck), in / m (elbow muscle area)||a single dose should not exceed 30 ml, a dose of more than 15 ml is divided into two injections and injected in different places|
|Pigs||1 (for weight up to 150 kg), 2.5 (for each additional 50 kg, once)||p / sh (area of the knee fold or behind the ear, in / m||a dose of more than 10 ml is divided into two injections and administered on the left and right sides|
|Sheep, goats||1 (for weight up to 50 kg), 6 (for weight over 50 kg, once)||п / ш||once|
|Poultry (chickens, geese, turkeys, pigeons)||3-4||orally with water||once or divided and given 3-4 days|
|Pigeons||1 ml per 200 ml of water||orally with water||3-5 days|
*Kilograms to a Pounds conversion table
|Kilograms (kg)||Pounds (lb)||Pounds+Ounces
|0.1 kg||0.220 lb||0 lb 3.527 oz|
|1 kg||2.205 lb||2 lb 3.274 oz|
|5 kg||11.023 lb||11 lb 0.370 oz|
|10 kg||22.046 lb||22 lb 0.740 oz|
After the last application of the drug, slaughter of animals and poultry for meat is allowed after 7 days. Meat obtained before this date can be used only for feeding carnivores and making meat and bone meal, and milk – to feed non-productive animals. People should not eat milk and eggs.
Atropine is used as an antidote.
Do not prescribe to females in the last third of pregnancy, breeding breeders during the mating season, laying hens and depleted animals.
Do not use together with pyrantel, morantel, organophosphorus drugs, neostigmine.
In a dry, dark place at a temperature of +1 to +25 ° C.