Brovseptol (sulfadimidine sodium salt, sulfadiazine sodium, trimethoprim), 33g (6.6g*5pcs)

powder for solution for injection

The kit includes a vial (8 ml) – 0.9% isotonic sodium chloride solution.

Storage

1 g of the drug contains:

sulfadimidine sodium salt – 300 mg

sulfadiazine sodium salt – 300 mg

trimethoprim water-soluble 30% – 400 mg

Description

Light yellow powder, homogeneous, with a faint specific odor.

Pharmacological properties

Combined antibacterial drug with a broad spectrum of action.

Sulfadimidine and sulfadiazine are antimicrobial bacteriostatic agents from the group of sulfanilamides. Sulfadimidine has a short-term effect, sulfadiazine – a medium-term effect.

Both sulfanilamides are similar in their spectrum of properties and are active against gram-positive and gram-negative microorganisms – Bordetella spp., Corynebacterium spp., Haemophilus spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Stahycco sco.

The mechanisms of antimicrobial action of sulfadimidine and sulfadiazine are also similar and are due to impaired synthesis of folic acid in bacterial cells. Both sulfanilamides are similar in structure to para-aminobenzoic acid (PABA), so they are competitive inhibitors of dihydropteroate synthetase. This leads to disruption of the synthesis of tetrahydrofolic acid, which is necessary for bacteria to synthesize purines and pyrimidines.

Trimethoprim is an antibacterial agent, the chemical structure of which is a derivative of diaminopyrimidine. Acts bacteriostatically against gram-positive and gram-negative microorganisms – Actinomyces spp., Bacillus anthracis., Bordetella spp., Brucella spp., Cloceldium spp., Corynebacterium spp., Escherichia coli, Haemophilus spp., Klebsiella s., Klebsiella s. , Salmonella spp., Stahylococcus spp., Streptococcus spp., Sampylobacter spp. The mechanism of action is associated with the inhibition of the enzyme dihydrofolate reductase in the synthesis of tetrahydrofolic acid. This leads to a lack of folate, the main cofactor in the synthesis of nucleic acids, due to which bacteria disrupt the production of nucleic acids and protein.

The combination of two sulfanilamides and trimethoprim expands the antimicrobial spectrum of action of the drug and reduces the likelihood of the formation of resistant strains in pathogenic microflora. The mechanism of action of the drug is the sequential inhibition of enzymes involved in the synthesis of folic acid, which, in turn, inhibits the synthesis of thymidine by bacterial cells.

Sulfanilamides are rapidly adsorbed from the injection site and distributed throughout the animal’s body. Their therapeutic level is observed for 24 hours. About half is extracted by the kidneys unchanged by glomerular filtration, in the alkaline reaction of urine, their excretion is enhanced, a small amount is excreted in the bile. Compared with the concentration of sulfonamides in blood plasma, their level in the kidneys is higher, and in the skin, liver, lungs – lower.

Trimethoprim is rapidly absorbed from the injection site and is well distributed in animals. Its maximum concentration is observed 4 hours after drug administration. The half-life in plasma is 8-10 hours. During the first 24 hours, up to 60% is excreted by the kidneys, mainly by glomerular filtration and tubular secretion, with up to 90% of them unchanged, the rest – in the form of inactive metabolites. A small amount (4%) is excreted in the bile.

Indication

Treatment of animals for diseases caused by microorganisms sensitive to sulfadimidine, sulfadiazine and trimethoprim:

• cattle, sheep – septicemia, necrotic pododermatitis, abscesses, respiratory diseases (rhinitis, bronchitis, pneumonia), gastrointestinal tract (anaerobic dysentery of lambs, gastroenteritis), genitourinary system (vaginitis, urethritis, metritis, mastitis);
• pigs – enzootic pneumonia, bacterial agalactia (sows), dysentery, edema, erysipelas, salmonellosis, pasteurellosis;
• horses – diarrhea (foal), contagious metritis, duty, sputum;
• rabbits – gastroenteritis, colibacillosis, pasteurellosis, coccidiosis, pneumonia, infectious rhinitis.

Contraindication

Do not prescribe to animals with hypersensitivity to the active substances of the drug, impaired liver and kidney function, lactating animals and females in the last third of pregnancy.

Do not use simultaneously with paraaminobenzoic acid derivatives.

Storage conditions

In a dry, dark place, out of reach of children at a temperature of 0 to +25 ° C.

After opening the vial, store the drug in the refrigerator and use within 6 days.

Expiration date

2 years

Method of application and dosage

Before use, the drug is combined with sodium chloride 0.9% solution included in the kit. To 3.3 g of the drug add 8 ml of sodium chloride, to 6.6 g of the drug – 16 ml and administered intramuscularly in the following doses:

• cattle, sheep, horses, pigs – 0.6-0.8 ml per 10 kg of body weight;
• rabbits – 0.1-0.15 ml per 1 kg of body weight.

The injection is repeated 2-4 times in 24 hours. The optimal course of treatment is 5 days. If the clinical symptoms of the disease have not disappeared completely, the course is extended for 2 days.

Injections larger than the following values ​​are divided into several parts and injected in different places:

• small animals, young animals – 10 ml;
• large and adult animals – 20 ml.

For cattle with bacterial diseases of the uterus, udder and hooves of the pelvic extremities, slow intra-arterial administration is allowed.

*Kilograms to a Pounds conversion table

Reservation

Do not use a solution of novocaine to dilute the drug.

With long-term use of the drug may be allergic reactions (skin rash, urticaria), itching, crystalluria, blood disorders (leukopenia, agranulocytosis, thrombocytopenia).

Goats are hypersensitive to sulfonamides, so they should be administered with extreme caution.

Salicylates and phenylbutazone may interfere with the binding of sulfonamides to plasma proteins and increase the toxicity of sulfonamides. Derivatives of paraaminobenzoic acid (novocaine, tetracaine, procainamide hydrochloride) reduce the antimicrobial activity of sulfonamides.

After the last application of the drug slaughter of animals and poultry for meat is allowed in 10 days. People can eat milk in 4 days. Meat and milk obtained earlier than this period are disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.