Brovfom (furazolidone, oxytetracycline hydrochloride, metronidazole), 100g

powder for oral use

1 g of the drug contains:

furazolidone – 70 mg

oxytetracycline hydrochloride – 30 mg

metronidazole – 100 mg

Description

The powder is light yellow, insoluble in water.

Pharmacological properties

A complex antimicrobial drug with a broad spectrum of action.

Oxytetracycline is a bacteriostatic antibiotic. Acts on gram-positive microorganisms – Streptococcus spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Gram-negative microorganisms – Brucella spp., Haemophilus spp., E. coli, Pasteurella spp., Klebsiella spp., Klebsiella spp. ., protozoa Protozoa, Mycoplasma spp., Rickettsia spp., Chlamydia chlamydia. The mechanism of action is to disrupt protein synthesis and reduce the permeability of the cytoplasmic membrane of bacteria.

Metronidazole belongs to the group of 5-nitroimidazole and has antiprotozoal and antimicrobial properties. The mechanism of its action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic bacteria and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of a microbial cell, inhibits the synthesis of its nucleic acids, which leads to the death of the microorganism. Effective against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, obligate anaerobic bacteria Bacteroides spp. – B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus, Fusobacterium spp., Veillonela spp., Some gram-positive bacteria Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.

Furazolidone is a synthetic antibacterial and antiprotozoal agent, a derivative of nitrofuran. In bacteria, it disrupts the process of cellular respiration, inhibits the biosynthesis of nucleic acids, blocks the enzyme system. Depending on the concentration gives a bacteriostatic or bactericidal effect. Active against gram-negative Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Klebsiella spp., Citrobacter spp., Gram-positive cocci Streptococcus spp., Staphylococcus spp., Protozoa Giardia, Trichomonas. Resistance to furazolidone develops slowly. Activates phagocytosis, does not suppress the immune system.

Oxytetracycline is gradually absorbed after oral administration. The maximum concentration in blood is reached in 30-60 minutes and remains at therapeutic level within 48 hours. The half-life in dogs is approximately 4-6 hours. Oxytetracycline penetrates almost all organs and tissues, but the maximum level is observed in the lungs, liver, bile, reproductive organs and kidneys. Concentrations in the lungs, gastrointestinal tract, muscles and spleen are the same as in blood plasma. Low concentration is observed in the cerebrospinal fluid, it does not reach therapeutic levels. The antibiotic penetrates the blood-brain barrier and the placenta. Metabolites are formed in small quantities, excreted mainly in urine and bile, in lactating animals – with milk.

Metronidazole after oral administration is rapidly and completely absorbed from the gastrointestinal tract, easily penetrates into organs and tissues. The degree of its distribution reaches 70-95% of the animal’s body weight. Has a high permeability. Reaches bactericidal concentration in most tissues and body fluids, including brain, cerebrospinal fluid, abscesses, saliva, bile, sexual secretions, amniotic fluid, passes the blood-brain and placental barrier. Vd in adults is approximately 0.55 l / kg. C _max in the blood depending on the dose is 6-40 μg / ml. Time to reach C _max– 1-3 years. Plasma protein binding is 10-20%. About 30-60% of metronidazole is metabolized by hydroxylation, oxidation and glucuronidation. The major metabolite (2-oxymetronidazole) also has antiprotozoal and antimicrobial properties. T1 / 2 with normal liver function – 8 hours (6-12 hours). The kidneys excrete 60-80%, unchanged – 20%, with feces – 6-15%. Renal clearance is 10.2 ml / min.

Furazolidone after oral administration is poorly absorbed in the gastrointestinal tract and acts mainly in the intestine. Once absorbed, it spreads rapidly to tissues, including the central nervous system. The concentration in the blood increases in parallel with the decrease in the amount of furazolidone in the intestine. Within an hour after oral administration, it is detected in the blood, in 2 hours its content in the blood and urine reaches a bacteriostatic concentration, which is maintained for 12 hours. It does not form high concentrations in blood and tissues (including kidneys), because it is rapidly metabolized in the liver, becoming an amino derivative. It is excreted mainly by the kidneys (65%), partly with bile, reaching high concentrations in the intestinal lumen, making it effective in intestinal infections.

Method of application and dosage

• dogs, cats – 0.15-0.2 g (equivalent to 10.5-14 mg of furazolidone, 4.5-6 mg of oxytetracycline hydrochloride, 15-20 mg of metronidazole) per 1 kg of body weight, 3 times a day, the course – 4-7 days;
• fur animals (foxes, polar foxes, minks) :
  – adult animals – 0.2-0.25 g (equivalent to 14-17.5 mg of furazolidone, 6-7.5 mg of oxytetracycline hydrochloride, 20-25 mg of metronidazole) per 1 kg body weight, 3 times a day, course – 3 days;
  – young animals at weaning – 1-1.5 g (equivalent to 70-105 mg of furazolidone, 30-45 mg of oxytetracycline hydrochloride, 100-150 mg of metronidazole) per 10 heads, daily, course – 14 days;
• pigeons – 3-4 g (equivalent to 210-280 mg of furazolidone, 90-120 mg of oxytetracycline hydrochloride, 300-400 mg of metronidazole) per 1 kg of feed, daily, course – 7-10 days.

Reservation

Indication

Treatment and prevention of animals for diseases caused by microorganisms and the simplest, sensitive to the active substances of the drug:

• dogs, cats – gastrointestinal diseases, prevention of complications after childbirth and surgery;
• fur animals (foxes, foxes, minks) – enteritis, eimeriosis (liver coccidiosis);
• pigeons – histomonosis, eimeriosis, salmonellosis, trichomoniasis.

Contraindication

Do not prescribe to animals with hypersensitivity to the active substances of the drug, CNS lesions, productive animals, females during pregnancy and lactation.

Do not use simultaneously with ephedrine hydrochloride, phenomine, ethanol-containing drugs.

Storage conditions

In a dry, dark place at a temperature of +4 to +25 ° C.

Feed the mixture to the animals during the day!

Expiration date

3 years.