TIM TIL 250 (Tylosin tartrate, Tiamulin hydrogen fumarate)
Arthritis; Erysipelas; Brucellosis; Dysentery; Enteritis; Campylobacteriosis; Colibacteriosis; Hoof rot; Listeriosis; Leptospirosis; Mycoplasmosis; Pasteurellosis; Peritonitis; Pneumonia; Salmonellosis; Sepsis; Chlamydia
1 ml of the drug contains:
thiamulin hydrogen fumarate – 145 mg
tylosin tartrate – 105 mg
The liquid is light yellow, transparent.
Combined bacteriostatic drug.
Tiamulin – a semi-synthetic antibiotic from the group of pleuromutilin, acts bacteriostatically against gram-positive microorganisms – Erysipelotrix spp., Staphylococcus spp., Streptococcus spp. , mycoplasmas – M. bovis, M. hypopneumoniae, M. hyorhinis, M. synoviae, M. hyosynoviae, Ureoplasma spp. etc., leptospira – Leptospira spp., spirochetes – S. hyodysenteriae, S. innocens, treponemes – T. hyodysenteriae, chlamydia – Chlamydia spp. The mechanism of antibacterial action is due to inhibition of bacterial protein synthesis by binding to the 70S subunit of ribosomes of microorganisms and disruption of the formation of the complex “mRNA-tRNA”.
Thilosin is an antibiotic from the group of macrolides, inhibits protein synthesis in bacteria, acts against gram-positive microorganisms – Actinomycos spp., Clostridium spp., Corynebacterium spp., Streptococcus spp., Leptospira spp. spp., Fusobacterium spp., Haemophilus spp., Pasteurella spp., Salmonella spp., B. bronchiseptica, P. mirabilis, E. coli, mycoplasma – Mycoplasma spp., chlamydia – Chlamydia spp., treponema – Treponema spp., rickettsiae – Rickettsia spp., Inhibits the action of some strains of Mycoplasma spp., Chlamydia spp., Ureaplasma spp., Rikettsia spp.
After oral administration, tiamulin is rapidly absorbed in the intestine; the half-life is 3-6 hours. According to the degree of impact on the body belongs to moderately dangerous substances (hazard class 3 according to GOST 12.1.007-76); LD50 when administered orally to white mice is 700 mg / kg body weight. Biologically transformed in the liver, excreted mainly in the feces.
After oral administration, tylosin is rapidly absorbed from the gastrointestinal tract. Therapeutic concentrations are stored in the serum for 6-8 hours. It is metabolized and excreted mainly in the urine, partly in the feces, in laying hens – with eggs, in lactating animals – with milk.
Treatment and prevention of animals and poultry for diseases caused by gram-positive, gram-negative and other microorganisms sensitive to thiamulin and tylosin:
- poultry (chickens, turkeys, geese, ducks and their young) – bronchitis, mycoplasmosis, Escherichia coli, pasteurellosis, diseases of the gastrointestinal tract and respiratory organs;
- pigs – erysipelas, dysentery, ileitis, leptospirosis, listeriosis, campylobacteriosis, colibacillosis, pasteurellosis, salmonellosis, infectious gastroenteritis, spirochetic enterocolitis, atrophic rhinitis, enzootic pneumonia, actinobacillary pleuropitis.
Method of application and dosage
The drug is administered orally with drinking water.
Doses of the drug for different species of animals are listed in the table.
|Animal species||Dose, ml||Course of application|
|per 1 liter of drinking water||per 10 kg of body weight|
|Poultry (chickens, turkeys, geese, ducks and their young)||1||3-5 days|
|Young poultry (prevention)||0.5||1-5, 18-20 days of life, daily|
|Pigs (enzootic pneumonia, mycoplasmal arthritis)||1-1.2||3-5 days|
In 8-10 days after completion of treatment of pigs from dysentery and ileitis, it is advisable to carry out preventive treatment with this drug or other antimicrobial agent for oral administration (Brovamulin-100, Brovamulin-plus, etc.).
After the last application of the drug, slaughter of pigs and poultry for meat is allowed in 10 days. Meat obtained before this date is disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.
Do not prescribe to animals with hypersensitivity to the active substances of the drug, pregnant sows in the first month of pregnancy, breeding boars, laying hens during the laying period.
Do not use concomitantly with penicillins, cephalosporins and lincomycin. Do not use coccidiostats based on polyester iontophores (monensin, narasin, salinomycin, etc.) during treatment with the drug and for at least 7 days before and after it.
In a dry, dark place at a temperature of +5 to +25 ° C.
After opening the vial, store the drug in the refrigerator and use for 20 days.