Metronidazole – antimicrobial drug for the treatment of bacterial and protozoal infections
Metronidazole belongs to the drugs of the 5-nitroimidazole group (5-NIMZ). These are highly active broad-spectrum antimicrobials for the systemic treatment of infections caused by obligate anaerobic bacteria and a number of infectious diseases caused by protozoa. In addition, 5-NIMZ are also active in relation to individual representatives of facultative anaerobes (microaerophiles) and, accordingly, are effective in the clinic for infections caused by these microorganisms. 5 – NIMZ – synthetic, low molecular weight compounds containing a nitro – group (NO2) at position 5 of the imidazole ring. According to its biological properties and the mechanism of antimicrobial action, 5-NIMZ is fundamentally different from imidazole derivatives with antifungal activity. Imidazole antimycotics have a more complex chemical structure, in the structure of their molecule in the imidazole ring there is no nitro-group or any other substituents.