Galastop Ceva 7 ml

Trade name of the medicinal product: Galastop.
International non-proprietary name: cabergoline.
Dosage form: oral solution.
In its composition, the drug as an active ingredient contains 50 μg of cabergoline base, and as an auxiliary component, purified coconut oil up to 1 ml.

In appearance, Galastop is a clear oily liquid from colorless to pale yellow.

Galastop is produced in packs of 3, 7, 15 and 24 ml in dark glass vials with a screw cap and packed in individual cardboard boxes, in which the instructions for use of the drug are placed. Additionally, each bottle is supplied with a graduated glass pipette in a protective case or a dosage plastic syringe.

Store the drug in the manufacturer’s sealed packaging, in a dry, dark place at a temperature of 5 ° C to 25 ° C.

The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of manufacture and 12 days after opening the bottle. It is forbidden to use the medicinal product after its expiration date.

Galastop should be kept out of the reach of children.
Unused medicinal product is disposed of in accordance with legal requirements.

II. Pharmacological properties
Pharmacotherapeutic group of the drug: dopaminomimetics.
Cabergoline, a derivative of ergoline, has the properties of an agonist of dopamine receptors, which leads to inhibition of the secretion of prolactin by the pituitary gland, the main hormone of lactogenesis. A decrease in prolactin levels prevents lactation and contributes to the disappearance of clinical signs of false pregnancy in bitches.

After oral administration, the peak of suppression of prolactin secretion is reached after 4-8 hours and lasts for several days, depending on the dose. The antiprolactin effect of cabergoline is much longer than that of methergoline, bromocriptine and pergolide.

Cabergoline is excreted mainly in feces and, to a lesser extent, in urine.
When administered in high doses, cabergoline, like other ergoline derivatives, has an emetic and hypotensive effect.

According to its famakotoxicological properties, the drug belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76).

III. Application Procedure
Galastop is used in bitches for the treatment of false pregnancy and suppression of lactation in bitches according to clinical indications (for example, during the period of early weaning of puppies).

A contraindication to the use of Galastop is the individual hypersensitivity of the animal to cabergoline.

It is forbidden to apply Galastop to pregnant bitches due to the high probability of abortion before 35-40 days of pregnancy, lactating bitches during the period of feeding suckling puppies, animals with renal and hepatic insufficiency, as well as animals in a state of hypotension.

Galastop is administered orally with food or forcibly on the tongue at a dose of 0.1 ml per 1 kg (3 drops in 0.1 ml) of the animal’s weight once a day for 4-6 days.
In case of an overdose of the drug, vomiting and hypotension are possible. In this case, it is recommended to carry out symptomatic therapy aimed at reducing the absorption of the drug from the gastrointestinal tract, restoring blood pressure and suppressing vomiting using drugs of the dopamine antagonist group, for example, metoclopramide.

In very rare cases, some animals in the first two days of treatment may experience a single vomiting, lack of appetite and drowsiness, which go away on their own and do not require discontinuation of the drug.
In case of the appearance of indomitable vomiting, the administration of the drug should be canceled.

If one or more doses of a drug are missed, treatment should be resumed as soon as possible in the prescribed dosage and regimen.

At the recommended doses, Galastop is generally well tolerated by dogs.
Rarely possible: vomiting and anorexia, hypotension, lethargy, muscle tremor and ataxia. Side effects are usually mild and in most cases go away on their own after discontinuation of the drug.

Very rarely, in sensitive animals to ergoline derivatives, an allergic reaction may develop in the form of itching, edema, dermatitis and urticaria, which disappear after discontinuation of the drug and the use of antihistamines.
Galastop should not be used in conjunction with dopamine antagonists, due to the competitive interaction of which the effectiveness of the drug decreases, as well as with drugs that have antihypertensive and anesthetic effects.

The drug is not intended for the treatment of productive animals.

IV. Personal precautions
When working with Galastop, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines.
Women of childbearing age, especially during pregnancy and lactation, should avoid direct contact with the drug, and rubber gloves should be used as protection.

In case of accidental contact of the drug on the skin or mucous membranes of the eyes of a person, you should immediately wash off the drug with plenty of running water and contact a medical institution (you should have instructions for use of the drug or a label with you).