Cestal PLUS for DOGS
Anti-trematode, anti-nematode and anti-cestode veterinary drugs – praziquantel, pyrantela embonate, fenbendazole.
Praziquantel is a pyrazinisoquinolone derivative that is rapidly absorbed through the outer shell of tapeworms, resulting in damage and contraction.
The consequence of a violation of the penetrating properties of the membranes is the paralysis of parasites. Praziquantel is rapidly absorbed in the alimentary canal.
Its highest concentration in blood plasma is reached within 1 – 2 hours after administration, it is rapidly metabolized and excreted in the form of metabolites in the urine.
Pyrantel embonate, a tetrahydro pyrimidine derivative, acts as a cholinergic antagonist, causing spastic paralysis of round helminths by depolarizing neuromuscular blockade. The maximum concentration of pyrantel embonate in blood plasma is reached after 2 to 4 hours.
Pirantela embonate is excreted in the feces and urine within 24 hours.
Fenbendazole belongs to the benzimidazole group.
Soluble in formic acid.
The mechanism of action of fenbendazole is a violation of glucose transport, a disorder of microtubular function and a decrease in the activity of fumarate reductase synthesis in the body of helminths.
This action causes paralysis and leads to the death of helminths.
Inhibition of the synthesis of fumarate reductase leads to a decrease in the level of glycogen in the body of parasites. Fenbendazole inhibits the polymerization of tubulin in microtubulin, as a result of which the intracellular transport of nutrients and metabolic substances (adenosine triphosphoric acid and glucose) is impaired.
1 tablet (780 ml) contains:
Pirantela embonate – 144 mg
Praziquantel – 50 mg
Fenbendazole – 200 mg
Excipients: lactose, wheat starch, povidone (K-90), talc, magnesium stearate, dry yeast, flavoring agent, purified water.
Indications for use:
Combined highly effective drug for the treatment and prevention of ascariasis, hookworm infections, cestodoses and trichurosis.
Low-toxic for warm-blooded animals, well tolerated by dogs, in the recommended doses does not have embryotoxic and teratogenic properties.
Thanks to the liver-flavored additive, the preparation is well eaten by dogs.
Deworming of dogs with nematodes and cestodes: Toxocara canis, Toxascaris leonina; Ancylostoma caninum, Uncinaria stenocephala; Taenia species, Dipylidium caninum, Echinococcus species; Trichuris vulpis.
Method of application and dosage:
The tablets are fed to animals forcibly or with feed (with a piece of meat, sausage, etc.).
You do not need to follow a pre-hunger diet.
For prophylaxis, the drug must be used once every three months.
For treatment, it is prescribed once. In case of severe infestation, the treatment should be repeated after 14 days.
Orally at a dose of 1 tablet per 10 kg of body weight of the dog (equivalent to praziquantel – 5 mg / kg, pyrantel embonate – 14.4 mg / kg, fenbendazole – 20 mg / kg).
Small breed puppies and dogs:
less than 2 kg of body weight – 1/4 tablet
2 – 5 kg body weight – 1/2 tablet
5-10 kg body weight – 1 tablet
Medium breed dogs:
10 – 20 kg body weight – 2 tablets
20 – 30 kg body weight – 3 tablets
Large breed dogs:
30 – 40 kg body weight – 4 tablets
40-50 kg body weight – 5 tablets
Do not use in animals with hypersensitivity to the components of the drug, weakened and sick animals The drug can be used in puppies from 3 months of age.
Store in a dry, dark place at a temperature of 15 to 25 ° C, out of the reach of children and animals, separately from food and feed.