Eprinomectin antiparasitic solution solution for external use, 0,3 ml 6 pipettes

1 pipette for cats below 2,5 kg bodyweight

Description

The solution is colorless or light brown, transparent.

Composition

1 ml contains:
fipronil – 83 mg
S-methoprene – 100 mg
eprinomectin – 4 mg
praziquantel – 83 mg

Pharmacological properties

Contact insectoacaricide, effective against preimaginal and imaginal forms of ectoparasites (lice, fleas, trichophytons, ticks) and endoparasites (gastrointestinal and pulmonary nematodes, heartworms and bladder worms).
Fipronil belongs to the group of phenylpyrazoles, has insecticidal and acaricidal effects. Fipronil and its metabolite fipronil sulfone disrupt processes in ligand-gated chloride channels, block the work of the neurotransmitter gamma-aminobutyric acid (GABA), reduce sensitivity (D), desensitize (N) gated glutamate channels (Glu, unique invertebrate ligand-gated chloride channels), block pre- and postsynaptic transfer of chlorine ions through cell membranes. This leads to uncontrolled activity of the CNS, disruption of nerve impulse transmission and death of arthropods (insects and ticks). Does not affect the CNS of warm-blooded animals.
S-methoprene is an insect growth regulator, an analogue of juvenile hormone. Stimulates the formation of chitin and disrupts the development of insects at all stages of metamorphosis. By acting on the hormones of young insects and binding to hormone receptors, it prevents insects from progressing to the next developmental stages, including the transformation of larvae into adults (imagos), thus interrupting the reproductive cycle. The ovicidal effect on animals is due to the direct penetration of S-methoprene into the shell of newly laid eggs or its absorption through the cuticle of adult insects.
Eprinomectin belongs to macrocyclic lactones, has a broad spectrum of antiparasitic activity against gastrointestinal nematodes (larvae and adults) – Bunostomum phlebotomum, Cooperia spp., Haemonchus placei, Nematodirus helvetianus, Oesophagostomum spp., Ostertagia spp., Trichostrongylus spp., Trichocephalus spp., Trichuris spp., respiratory nematodes – Dictyocaulus viviparus, ixodid ticks – Rhipicephalus spp., sarcoptic mange mites – Sarcoptes bovis, gadfly larvae – Hypoderma bovis, Hypoderma lineatum, lice – Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus, blood-sucking dipterans – Haematobia irritans, etc. Like other macrocyclic lactones, it acts as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA) in nerve cells and binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. This disrupts the transmission of nerve impulses, leading to paralysis of the parasites and their death or excretion from the body. In addition, eprinomectin affects the reproductive processes of some parasites, in particular disrupting oogenesis and egg laying.
Praziquantel is a synthetic isoquinoline-pyrazine derivative, active against intestinal tapeworms of all stages of development – Dipylidium caninum, Taenia taeniaeformis and Echinococcus multilocularis. It increases the permeability of helminth cell membranes to calcium ions, which causes generalized muscle contraction of the parasites, which turns into persistent paralysis and leads to their death.
After application of the drug to the skin, fipronil and S-methoprene are gradually distributed over the entire surface of the animal’s body, accumulate in the epidermis, hair follicles and sebaceous glands and, being slowly released, provide long-term protection of the animal from ectoparasites.
After treatment of cats with the drug, fleas and ticks – Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, I. ricinus, Haemaphysalis longicornis, H. flava, H. campanulata – die within 24 hours (fleas) and 48 hours (ticks).
A single treatment provides protection of animals from ticks for up to 5 weeks, and from fleas – for up to 7 weeks.
Eprinomectin and praziquantel have a systemic effect. The maximum concentration of eprinomectin in the blood plasma is reached approximately 48 hours after treatment, and praziquantel – 6 hours after treatment. They are excreted with feces and urine. Studies have not revealed any pharmacodynamic or pharmacokinetic interactions between fipronil, S-methoprene, eprinomectin and praziquantel in mammals.

Indications

Prophylaxis and treatment of cats with fleas (Ctenocephalides spp.), parasitiform and scabies mites (Ixodes ricinus, Dermatocentor variabilis, Rhipicephalus sanguineus), lice (Felicola subrostratus), flea allergic dermatitis, feline notoedrosis (Notoedres cati), gastrointestinal nematodoses – L3, L4 larvae, immature and adults of Toxocara cati, L4 larvae and adults of Ancylostoma tubaeforme, Ancylostoma ceylanicum, adults of Toxascaris leonina, Ancylostoma brazilienze), cestodes – Dipylidium caninum, Taenia taeniaeformis, Echinococcus multilocularis, adults of Joyeuxiella pasqualei, Joyeuxiella fuhrmanni, pulmonary nematodoses – L3, L4 larvae and adults of Aelurostrongylus abstrusus, Troglostrongylus brevior, Capillaria spp., bladder nematodes – Capillaria plica.
Prevention of heartworm disease (Dirofilaria immitis). Reduction of the level of infection with feline liver fluke (Opisthorchis felineus) in mixed infections.

Contraindications

Do not administer to animals with hypersensitivity to the active ingredients of the drug, sick, exhausted and weakened animals. Do not use in rabbits.

Method of application and doses

The drug is applied once to dry, intact skin. The minimum dose is 10 mg of fipronil, 12 mg of S-methoprene, 0.5 mg of eprinomectin and 10 mg of praziquantel per 1 kg of body weight.

When treating cats weighing more than 7.5 kg, a combination of applicators of different volumes is used.
Before treatment, remove the pipette from the packaging and, holding it vertically, cut off the spout. Part the animal’s fur and distribute the contents of the pipette on the area between the base of the skull and the shoulder blades.
Treatment against fleas and ticks is carried out once every 4 weeks if there is a risk of concomitant gastrointestinal nematodoses. In its absence, prevention of flea and tick infestation can be carried out with insecticidal/acaricidal preparations (for example, based on fipronil with/without S-methoprene).
One treatment is sufficient for lice bites.
For the prevention of dirofilariasis, treatment is carried out monthly, starting at least 1 month before the onset of activity of blood-sucking insects and continuing for about a month after their disappearance. For optimal effect, the drug is used on the same date each month. If the animal was treated against heartworms with another agent, then Eprinil is used for the first time 1 month after the previous treatment. The drug is safe for cats infected with mature forms of heartworms. However, cats over 6 months of age should be preliminarily examined for the presence of sexually mature helminths.
For the treatment of gastrointestinal nematodoses and cestodes, a single treatment is also sufficient. In the absence of indications for monthly use, the drug can be included as a component of seasonal deworming.
For pulmonary nematodoses, it is used once, repeated treatment is possible after a month at the discretion of the veterinarian.
For the treatment of bladder nematodoses, a single treatment is also performed.

Precautions

There are no data on the safety of the drug during pregnancy and lactation, therefore the decision to use the drug during these periods should be based on the veterinarian’s assessment of the risk/benefit for the animal’s health.
Simultaneous use of other macrocyclic lactones should also be based on such an assessment.
Rubber gloves should be worn when working with the drug. Smoking, eating and drinking are prohibited. After treatment, wash hands with soap. Avoid contact with exposed skin and eyes. Do not inhale the product! If the product accidentally gets on the skin or mucous membranes, rinse them with water.
Do not pet animals after treatment and do not allow small children to come into contact with treated animals until the product has completely dried. People with hypersensitivity to the active ingredients of the product should avoid contact with it.
If the product enters the human body, immediately consult a doctor and show him the package insert for the product.

Storage conditions

In the manufacturer’s packaging, in a dry place inaccessible to children and animals, separate from food and feed at a temperature of 0 to +30 °C.

Shelf life

2 years.