PROPALIN (Phenylpropanolamine HCl) (Proin analog)

Properties and actions

Phenylpropanolamine HCl

Propalin’s active ingredient – phenylpropanolamine hydrochloride (FPA)- acts on alpha- and, to a lesser extent, on beta-adrenergic receptors, and also indirectly increases the release of norepinephrine from the depot. It has a direct effect on the muscles of the lower urinary tract (increases tone and enhances the contraction of the urethral sphincter). When administered orally, FPA is rapidly absorbed from the gastrointestinal tract. It is excreted from the body in the urine in unchanged form or in the form of inactive metabolites. FPA reaches its peak plasma concentration after 1–2 hours. There is no accumulation of the drug during the treatment period.

Indications

Propalin is used in dogs for urinary incontinence due to functional insufficiency of the urethral sphincter.

Contraindications

Propalin is contraindicated for puppy and lactating animals, with hypersensitivity to the components of the drug.

Undesirable effects

Side effects and complications when using Propalin in accordance with the instructions for use of the medicinal product have not been established.

Interaction

Propalin is not recommended to be used simultaneously with other sympathomimetics, anticholinergic drugs, tricyclic antidepressants.

Application and dosage

Propalin is used in a mixture with food during feeding at a dose of 0.03 ml (0,0010 oz) per 1 kg (2.2 lbs) of body weight 2 times a day, or 0.02 ml (0,00067 oz) per 1 kg (2.2 lbs) of body weight 3 times a day. For dogs weighing 25 kg (55 lbs) or more Propalin is used in a dose of 0.75 ml (0,025 oz) per 25 kg (55 lbs) of body weight 2 times a day, or 0.5 ml (0,016) per 25 kg (55 lbs) of body weight 3 times a day. Over time, the dose of the drug can be reduced on an individual basis.

Propalin is intended for continuous use.

Storage conditions

Propalin should be stored with caution in a dry place, protected from direct sunlight, at a temperature of 15 ° C to 25 ° C.

Shelf life is

24 months from the date of manufacture, subject to storage conditions.

The shelf life after opening the bottle is 3 months.

Special warnings

When working with Propalin, you should follow the general rules of personal hygiene and safety measures provided for working with medicinal products for animals.

Do not use empty vials and used dispensing syringes for household purposes. Propalin is not used after the expiration date. Propalin should be kept out of the reach of children.

For animals only

Packaging

Propalin is produced in the form of a 5% solution for oral administration and is packaged in plastic vials with a volume of 30 or 100 ml, which, complete with a syringe-dispenser, are packed in a cardboard box.

Instructions for the drug Propalin

Marketing authorization holder : VETOQUINOL, SA (France)

Representative office : VETOKINOL S.A. (France)

Active ingredient: phenylpropanolamine (phenylpropanolamine) Rec.INN registered by WHO

Dosage form: PROPALINE oral solution

reg. No.: 250-3-8.16-3360 No. PVI-2-3.5 / 01750 dated 06.08.2016 – Validity of reg. beats not limited

Product form, composition and packaging

Solution for oral administration transparent, colorless 1 ml, phenylpropanolamine hydrochloride 50 mg.

Excipients: sorbitol solution.

Propalin is packaged in 30 and 100 ml bottles, hermetically sealed with screw caps with first opening control. The vials are packed in individual cardboard boxes complete with a graduated dispenser with a capacity of 1.5 ml. Each consumer package is supplied with instructions for use.