Amitrazin Forte ear spray ( amitraz clotrimazole )
Description
Oily yellowish liquid with a specific odor.
Storage
1 ml of the drug contains active substances:
amitraz – 2 mg;
clotrimazole – 10 mg.
Excipients: dimethyl sulfoxide, PEG-400.
Pharmacological power
Amitraz is an acaricide from the group of amidines, active against sarcoptoid mites (Otodectes spp., Psoroptes, Notoedres cati), as well as Demodex spp. Amitraz acts by contact, disrupting the octopamine receptors of the nervous system of the mite, which causes paralysis and death of parasites, has a negative effect on the reproductive organs of female mites, reducing egg production and viability.
Clotrimazole is an antifungal agent from the group of imidazole derivatives with a wide range of antifungal (Trichophyton, Epidermophyton, Microsporum) and weak antibacterial action (Streptococcus spp.). The mechanism of action of clotrimazole is to block the synthesis of nucleic acids and proteins, as well as the synthesis of ergosterol in fungal cells, which leads to damage to their cell membrane and cell death.
The drug is effective against resistant populations of mites resistant to chlorine and phosphoorganic insecticides. It penetrates and is deposited in the epidermis, hair follicles, sebaceous and sweat glands and has acaricidal, anti-inflammatory and emollient effects.
Application
Treatment of dogs, cats and fur animals with otodectosis, sarcoptosis, notohedrosis, demodectic mange and fungal skin diseases; at a joint course of a parasitic invasion and the infections caused by pathogenic fungi.
Dosage
At an otodectosis bury 0,2-0,5 ml of drug, depending on the size of an animal, in both ears (even in cases of defeat of only one). Preliminarily, the ear canal is cleaned of scabs and crusts with a swab moistened with the drug, for complete treatment of the ear surface, the auricle is folded in half lengthwise and lightly massaged. Treatment is performed once a day for 3 days until the disappearance of clinical signs of the disease (3-5 treatments).
In demodicosis, sarcoptosis and notohedrosis, the drug is applied to pre-cleansed affected areas of skin from the periphery to the center at a rate of 0.5 ml / kg body weight once a day for 2-3 days until the disappearance of clinical signs of the disease (6-8 treatments), additionally treat the skin around the affected areas with a width of at least 1 cm. With a large area of skin lesions, it is recommended to treat the affected areas first on one half of the animal’s body, a day later – on the other half of the body.
At fungal diseases processing of the affected places of skin of animals is carried out in the specified way once a day within 3-5 days.
Three drops of the drug from the vial with a dispenser and 12 drops of the drug from the vial with a dropper correspond to 0.5 ml.
Contraindication
Individual sensitivity to the components of the drug.
Do not use in pregnant and lactating females, as well as puppies and kittens under 2 months of age.
Reservation
Burning is possible in the presence of skin damage at the treatment site.
When handling animals, use plastic or rubber gloves.
Release form
Polymer bottles with a dropper stopper and a dropper dispenser of 10, 30 ml.
Storage
Dry dark place inaccessible to children at a temperature of 5 to 25 ° C.
Shelf life – 2 years.
For use in veterinary medicine!