Chlorhexidine Spray 0.05%, 100 ml
Composition of the medicinal product
active substance: chlorhexidine;
1 ml chlorhexidine bigluconate 0.5 mg
Excipients: purified water.
Dosage form
Solution for external use.
A clear, colorless, odorless liquid.
Pharmacological group
Antiseptic and disinfectants.
ATC code D08A C02.
Chlorhexidine bigluconate is a cationic biguanide. Chlorhexidine has amino groups in cellular proteins. Penetrates into the intracellular membranes of bacterial cells, settles on the cytoplasm and changes the function of the membrane, preventing oxygen consumption, which causes a decrease in ATP levels and cell death. Destroys DNA and disrupts DNA synthesis in microorganisms. Provides long-term persistent antimicrobial activity, prevents the multiplication of microorganisms for at least 6:00 after application of the drug.
Chlorhexidine bigluconate has a fast and pronounced effect on gram-positive and gram-negative bacteria (Treponema pallidum, Chlamidia spp., Ureaplasma spp., Neisseria gonorrhoeae, Gardnerella vaginalis, Bacteroides fragilis), protozoa (Trichomonasinal vagis. In the presence of blood and other organic substances, the antimicrobial activity of chlorhexidine digluconate does not decrease. Does not penetrate through intact skin. Practically not absorbed from the gastrointestinal tract. After accidental ingestion of 300 mg, the maximum concentration is reached after 30 minutes and is 0.206 μg / L. It is excreted mainly in the feces (90%), less than 1% is excreted by the kidneys.
Indications
Prevention of sexually transmitted infections (syphilis, gonorrhea, trichomoniasis, chlamydia, ureaplasmosis, genital herpes).
Disinfection of purulent wounds, infected burn surfaces; treatment of infections of the skin and mucous membranes in surgery, obstetrics, gynecology, urology (urethritis, urethroprostatitis), dentistry (rinsing and irrigation – gingivitis, stomatitis, aphthae, periodontitis, alveolitis).
Contraindications
Hypersensitivity to the components of the drug. Tendency to allergic reactions and allergic diseases, dermatitis, viral skin diseases. It is not recommended to use for the treatment of the conjunctiva and lavage of cavities, on wounds with a large surface, during operations on the areas of the central nervous system and the auditory canal, in ophthalmology, for introduction into the auditory canal.
Appropriate safety precautions for use
Avoid getting the drug inside the wound in patients with open traumatic brain injury, spinal cord injury, perforation of the tympanic membrane. If the solution gets on the mucous membranes of the eyes, they should be quickly and thoroughly rinsed with water. The contact with hypochlorite bleaching agents on fabrics that have previously been in contact with preparations containing chlorhexidine can cause brown stains on them. The bactericidal effect of the drug increases with increasing temperature. At temperatures above 100 ° C, the drug is partially decomposed.
If the drug gets on the mucous membranes of the eyes, they should be quickly and thoroughly rinsed with water. The drug is practically not absorbed in the stomach. If the product is accidentally swallowed, the stomach should be flushed using raw milk, raw egg, gelatin. If necessary, carry out symptomatic therapy.
Use during pregnancy or lactation
During pregnancy and lactation, the drug should be used only when the expected benefit to the mother outweighs the potential risk to the fetus / child. Do not process the surface of the mammary glands before feeding.
The ability to influence the reaction rate when driving or driving other mechanisms
Does not affect.
Children
Do not use in children under 12 years of age.
Method of administration and dosage
Apply externally. In case of microtraumas, treat the skin around the wound with a solution, then apply a napkin moistened with a solution to the wound and fix it with a bandage or plaster.
For the prevention of sexually transmitted infections, the drug is effective if it is used no later than 2:00 after intercourse. Before using the drug for the prevention of sexually transmitted diseases, you should empty the bladder, wash your hands and genitals. After that, with a stream of solution, treat the skin of the pubis, inner surfaces of the thighs, genitals. Introduce the contents of the bottle into the urethra (2-3 ml), women (1-2 ml), women into the vagina (5-10 ml) using a nozzle and hold for 2-3 minutes. Treat the skin of the inner surfaces of the thighs, pubis, genitals with a solution. After the procedure, you should not empty your bladder for 2:00.
Complex treatment of urethritis and urethroprostatitis is carried out by injecting 2-3 ml of chlorhexidine bigluconate solution into the urethra 1-2 times a day, the course of treatment is 10 days. Treat procedures every other day.
The solution of the drug is used in the form of irrigation, rinsing and applications – 5-10 ml of the solution is applied to the affected surface of the skin or mucous membranes with an exposure of 1-3
