Reversan (Atipamezole) Solution for Dogs and Cats (Antisedan, Revertor analog), 10 ml
It is used in dogs and cats to completely stop the sedative, analgesic, and side effects on the cardiovascular and respiratory systems of drugs such as Madison , and other drugs based on medetomidine hydrochloride.
Description
The liquid is colorless, transparent. solution for injection
1 ml of the drug contains:
atipamezole hydrochloride – 5 mg
Pharmacological properties
Atipamezole hydrochloride is a selective blocker of alpha-2-adrenoceptors, which stimulates the secretion of norepinephrine, which is the main neurotransmitter in the central and peripheral nervous system. This leads to stimulation, excitation of the sympathetic nervous system, stops the sedative, analgesic effect and other effects on the cardiovascular and respiratory systems of medetomidine hydrochloride or dexmedetomidine hydrochloride. After intramuscular injection is rapidly absorbed, the maximum concentration in blood plasma is reached in 10-15 minutes after administration. The volume of distribution (Vd) is 1-2.5 l / kg, the half-life is 2-3 hours.
Atipamezole hydrochloride is metabolized in the liver, a small amount is methylated in the kidneys. Metabolites are excreted mainly in the urine.
Method of application and dosage
The drug is administered intramuscularly or subcutaneously, once, after surgery or other manipulations.
The optimal dose of Reverson is correlated with the volume of previously administered drug Madison or other drugs based on medetomidine hydrochloride as follows: for dogs – 1: 1, for cats – 1: 2 (the dose of Reverson is twice less than the dose of Madison).
Examples of dose calculation for different species of animals are given in the table.
| Animal species | The dose of Madison | Reverson’s dose |
| Dogs | 0.4 ml per 10 kg of body weight | 0.4 ml per 10 kg of body weight |
| Cats | 0.4 ml per 5 kg of body weight | 0.2 ml per 5 kg of body weight |
*Kilograms to a Pounds conversion table
| Kilograms (kg) | Pounds (lb) | Pounds+Ounces (lb+oz) |
| 0.1 kg | 0.220 lb | 0 lb 3.527 oz |
| 1 kg | 2.205 lb | 2 lb 3.274 oz |
| 5 kg | 11.023 lb | 11 lb 0.370 oz |
| 10 kg | 22.046 lb | 22 lb 0.740 oz |
Reverson quickly returns the animal to full consciousness and reduces the period of possible cardiovascular depression and hypothermia.
Usually the effect of the drug begins within 5-10 minutes after administration. If the animal continues to be depressed, Reverson can be re-administered at the same dose 10-15 minutes after the first application.
Reservation
Occasionally the drug causes vomiting, salivation, shortness of breath, defecation. There may be isolated cases of hyperactivity and tachycardia, which disappear quickly.
Cats can develop hypothermia, so after administration of the drug it is better to place the animal in a quiet room.
If the animal is given a combination of medetomidine and butorphanol or ketamine, Reverson will only stop the action of medetomidine. In this case, Reverson should be administered no earlier than 30-40 minutes after sedation. If Reverson is used earlier, convulsions may occur.
Nonspecific central stimulants (eg, 4-aminopyridine) enhance the effect of the drug.
Indication
It is used in dogs and cats to completely stop the sedative, analgesic and side effects on the cardiovascular and respiratory systems of drugs such as Madison , and other drugs based on medetomidine hydrochloride.
Contraindication
Do not use in animals with hypersensitivity to the active substance of the drug, pregnant, lactating and productive animals.
Storage conditions
In a dry, dark place, out of reach of children at a temperature of +15 to +25 ° C.
After opening the vial, use the drug for 28 days.
Expiration date
2 years.
