Antisedan, 10 ml (atipamezole hydrochloride)
The composition of the drug
Solution for injection 0.5% sterile, clear, colorless, as the active substance contains atipamezole hydrochloride 5 mg / ml. Packed in glass bottles of 10 ml.
Pharmacological properties
The active substance atipamezole selectively blocks alpha2-adrenoceptors, which eliminates the sedative effect of medetomidine (Domitor), a stimulant of alpha2-adrenoceptors. The maximum concentration of the active substance in the blood is reached in 10-15 minutes. Atipamezole is oxidized mainly in the liver, a smaller part is methylated in the kidneys. Excreted mainly in the urine as metabolites. The half-life is 1 hour.
Indications for use
Elimination of sedative and analgesic effects of Domitor (medetomidine) in dogs and cats, as well as, if necessary, elimination of side effects of Domitor on the cardiovascular and respiratory systems.
Contraindication
Antisedan is not prescribed to pregnant animals, is not used to eliminate the effects of other sedatives.
Method of application and dosage
The drug is administered intramuscularly once, 15-60 minutes after Domitor. The sedative effect of the domitor is usually removed within 5-10 minutes. If necessary, it is possible to re-introduce the antisedan in 10-15 minutes. For dogs, the dose of antisedan in ml is equal to the dose of Domitor. For cats, the dose of antisedan in ml is equal to half the dose of Domitor.
Side effects
In dogs, hypotension is observed after the first 10 minutes after injection. In rare cases, vomiting, rapid breathing, involuntary defecation, shortness of breath and muscle tremor are possible. In cats, the introduction of Antisedan may develop normal hypothermia after anesthesia.
Special instructions
Due to the strong pharmacological action of atipamezole, it is necessary to avoid contact of Antisedan solution with the skin and mucous membranes. In case of contact with skin or mucous membranes, the contact site should be rinsed immediately with plenty of water.
Storage conditions
With caution (list B), in the manufacturer’s closed package, in a dry place, protected from direct sunlight, out of reach of children and animals. Separately from food and feed at a temperature of 15 ° C to 25 ° C – 3 years from the date of manufacture, after opening the bottle – no more than 4 weeks (28 days).