Brovitacoc Soluble Powder (CORID analog (Amprolium )

Composition
1 g of the drug contains:

amprolium hydrochloride – 125 mg

vitamin K3 (vicasol) – 2 mg

vitamin A (retinol) – 10,000 IU

Description
Powder of white or light yellow color, microgranular, with a specific odor.

Pharmacological properties
The drug suppresses the development of coccidia at the stage of the schizogony of the first and second generation, displaces vitamin B1 in the metabolism of carbohydrates. Carbohydrate deficiency leads to the death of protozoa.

Amprolium hydrochloride is practically not absorbed in the gastrointestinal tract, acting on coccidia on mucous and submucous membranes. In the recommended doses, it does not have a mutagenic, sensitizing, embryotoxic, and teratogenic effect, does not interfere with the development of immunity against coccidiosis.

The therapeutic concentration in the body is maintained for 24 hours. It is excreted mainly unchanged in the feces within 3-4 days.

Vitamins A and K3 increase the functional capacity of the epithelium and reduce hemorrhages on the intestinal mucosa.

Vitamin K provides the synthesis of prothrombin and thromboplastin in the liver, which is involved in blood coagulation. The pharmacological action is manifested on the 2-3rd day.

Vitamin A is a fat-soluble vitamin that plays an important role in the synthesis of proteins, lipids, mucopolysaccharides, regulates the balance of minerals, modulates the processes of differentiation of epithelial cells, participates in the development of secretory glands, keratinization processes, and regeneration of mucous membranes and skin.

When administered orally, it is well absorbed in the upper parts of the small intestine, then as part of chylomicrons, it is transported from the intestinal walls to the lymphatic system and through the thoracic duct into the bloodstream.

The maximum level of vitamin A esters in serum is reached after 3 hours. Vitamin A accumulates in stable ester forms in the liver parenchyma, is metabolized in the liver, excreted by the kidneys in the form of inactive metabolites, and partly with bile. Retinol excretion is slow – 34% of the dose taken is excreted from the body in 3 weeks.

Doses and method of administration

bird
prophylactically: chickens up to 2 months. age, daily – 0.9-1 g per 1 kg of feed; up to 4 months age – 0.7 g / kg; before laying – 0.4 g / kg feed; chickens of meat breeds, turkeys – 1 g / kg of feed for the entire growing period, and goslings, pigeons and pheasants – for the period of the threat of invasion;
for treatment: regardless of the type and age of birds – 2 g per 1 kg of feed or 1 liter of water for 5-10 days.

calves
prophylactically: 0.4-0.5 g / 10 kg of body weight for 3 weeks;
for treatment: 1 g / 10 kg (eimeriosis), or 1.5 g / 10 kg of body weight (cryptosporidiosis) for 5-10 days.

sheep, goats
prophylactically: 0.6 g / 10 kg for 3 weeks;
for treatment: 4 g / 10 kg of body weight for 5 days.

pigs
prophylactically: 0.4 g / 10 kg for 4-8 weeks;
for treatment: 2-4 g / 10 kg for 5 days.

rabbit
prophylactically: 1 g / l of water for 3 weeks;
for treatment: 2-2.5 g / l of water for 4-5 days.

dogs, cats
prophylactically: for females 10 days before delivery, drinking water is replaced daily with a 0.075% solution (per DV), which is 6 g / l of water;
for treatment: 2 g / 10 kg of body weight for 7-10 days.

Indications
Treatment and prevention of animals affected by eimeria:

• calves – E. bovis, E. cylindrical, E. ellipsoidae, E. zuernii, Cryptosporidium muris, C. parvus;

• sheep, goats – E. arloigni, E. faurei, E. intricata, E. ninaekohljakimovae;

• pigs – E. debliecki, E. scabra, E. spinosa, E. suis, Isospora suis;

• rabbits – E. magna, E. perforans, E. stiedae;

• carnivores – Isospora canis, I. ohioensis, I. rivolta, I. felis;

• chickens – E. acervulina, E. maxima, E. necatrix, E. tenella;

• turkeys – E. adenoeides, E. meleagrimitis;

• pheasants – E. colchii;

• geese – E. anseria, E. nocens, E. truncate;

• pigeons – E. labbeana.

Contraindications
Do not administer to laying hens and replacement chickens older than 4 months.

Storage conditions
In a dry, dark place, at a temperature from +4 to +20 ° С.

Shelf life
1 year.