Hepatoprotective for dogs
Hepatolic, 100 ml
Structure
1 ml of the drug contains active ingredients:
essential phospholipids – 60 mg,
methionine – 100 mg,
L-Ornithine 50 mg
milk thistle extract – 15 mg,
Helichrysum herb extract – 15 mg.
Excipients: potassium sorbate, sodium benzoate, xanthan gum, tween-80, propylene glycol, distilled water.
Suspension from light brown to dark brown with a specific odor of the constituents.
Pharmacological properties
ATСvet code QА05ВА. Complex functional feed additive for dogs and cats with liver diseases.
Hepatolic contains specific nutraceutical components that have membrane stabilizing, hepatoprotective, antioxidant properties. The complex of constituent biologically active substances improves the functional state of the liver and its detoxification function, contributes to the preservation and restoration of the structure of hepatocytes; normalizes the level of ammonia in the body of animals, accelerates the regeneration of liver cells.
The main component of the feed additive is the so-called essential phospholipids (EPL-substance), which is a highly purified fraction of phosphatidylcholine. The defining component of this fraction is dilinoleoylphosphatidylcholine. Essential phospholipids in their chemical structure are similar to endogenous membrane phospholipids, surpassing them in their functional properties due to their high content of polyunsaturated fatty acids, especially linoleic acid. Phospholipids are the main structural elements of cell membranes and organelles. They are involved in cell differentiation, division and regeneration. The functional significance of phospholipids is based on their amphiphilic properties, which allow regulating the permeability of the cell membrane. They improve the function of membranes, in particular ion exchange, the process of intracellular respiration, biological oxidation, affect the binding of enzymes of intracellular respiration in mitochondria, as well as the process of oxidative phosphorylation in the energy metabolism of cells. Under physiological conditions, the synthesis of phospholipids satisfies the normal needs of hepatocytes, which contain a sufficient amount of phospholipids. It is known that the structure of cell membranes and the function of enzyme systems are impaired in liver diseases. The biosynthesis of phospholipids is impaired, the deficiency of which leads to dysfunction of the cell membrane. These processes are especially pronounced in mitochondria, which are approximately 30% composed of phospholipids and in which the most important metabolic processes are carried out, including oxidative phosphorylation. With a deficiency of phospholipids, a violation of fat metabolism occurs, which leads to fatty degeneration of the liver. Due to its pharmacological properties, Hepatolic eliminates these disorders, promotes the regeneration of cell membranes, reactivates disturbed membrane-enzyme systems and receptors, increases the detoxifying ability of the liver and thus normalizes its function.
Silymarin has a hepatoprotective effect due to competitive interaction with receptors for the corresponding toxins in the hepatocyte membrane, thus exhibiting a membrane stabilizing effect, stimulates the synthesis of proteins (structural and functional) and phospholipids in damaged hepatocytes, thus accelerating regenerative processes. The action of flavonoids, to which silymarin belongs, is also due to their antioxidant properties and effects that improve microcirculation.
Helichrysum extract improves the general functional state of the liver, enhances the formation of bile and bile acids, improves the flow of bile through the biliary tract, enhances the secretory and motor functions of the gastrointestinal tract. It is widely used for various diseases of the liver, gallbladder and biliary tract: cholelithiasis, biliary dyskinesia, chronic cholecystitis, chronic hepatitis. Helichrysum extract has a pronounced antispasmodic effect on the bile ducts and the sphincter of the gallbladder, which, together with a mild tonic effect on the gallbladder, leads to an improvement in bile outflow, full release of the gallbladder, and the cessation of biliary dyskinesia. The presence of resin acids in the immortelle extract provides an antiparasitic effect against lamblia.
Biologically active substances of immortelle have a complex effect on the hepatobiliary zone, significantly enhance the drainage function of the liver, ensuring reliable elimination of metabolic products and toxins with bile.
In terms of the degree of impact on the body, a hepatolic belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76), in therapeutic doses it does not have an embryotoxic, teratogenic, carcinogenic and sensitizing effect.
Application
Hepatolic is prescribed to dogs and cats independently or as part of complex therapy for acute and chronic liver diseases of various etiologies, to normalize liver function and regeneration after endo and exotoxicosis, somatic and infectious diseases, and also to reduce the negative effects of drugs with hepatotoxicity.
Dosage
The drug is administered to dogs and cats orally, individually with a small amount of food or injected forcibly using a syringe dispenser 2-3 times a day for 3-5 weeks, at the doses indicated in the table:
Animal body weight | Single dose of suspension, ml | Suspension daily dose, ml |
Dogs | ||
up to 10 kg | one | 2 – 3 |
11 – 20 kg | 2 | 4 – 6 |
21 – 30 kg | 3 | 6 – 9 |
31 – 40 kg | four | 8 – 12 |
from 41 kg and more | five | 10 – 15 |
Cats | ||
up to 3 kg | one | 2 – 3 |
3 – 6 kg | 2 | 4 – 6 |
from 7 kg and more | 3 | 6 – 9 |
Contraindications
Hypersensitivity of the animal to the components of the feed additive, hepatic encephalopathy and epilepsy.
Release form
Bottles made of polymeric materials of 30 ml, 50 ml and 100 ml, complete with a syringe-dispenser and enclosed in a box.
Storage
In the manufacturer’s sealed packaging, in a dry, dark place out of the reach of children, separately from food and feed, at a temperature of 2 ° C to 25 ° C.
Shelf life
in a sealed package, subject to storage conditions – 2 years from the date of manufacture, after opening the bottle – no more than 21 days.