Lincomycin-Spectinomycin 10% Sterile Solution , 100 ml
Storage
1 ml of the drug contains the active substance:
lincomycin (hydrochloride) 50 mg;
spectinomycin (sulfate) 100 mg.
Excipients: benzyl alcohol, sodium hydroxide, dilute hydrochloric acid, water for injections.
Pharmacological properties
The combination of lincomycin-spectomycin is characterized by a broad spectrum of action due to the synergistic effect.
Lincomycin is a lincosamide antibiotic, a product of Streptomyces lincolnensis.Β Mechanism of action – inhibition of protein synthesis at the level of the ribosomal subunit 50S.Β Lincomycin acts on gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium spp., Actinobacillus spp., Bordetella spp., Some species of Nocardis and Actinomyces spp. Co., Especially effective).
Spectinomycin is an aminocyclic antibiotic derived from Streptomyces spectabilis.Β It acts mainly on gram-negative microorganisms (E. coli, Pasteurella multocida, Salmonella spp., Clostridium spp., Erysipelothrix rhusiopathiae, Haemophilus spp., Vibrio spp.), As well as mycoplasmas (Mycoplasma spp.).Β Mechanism of action – inhibition of protein synthesis at the level of the ribosomal subunit 30S.
Application
- Calves: treatment of animals with pneumonia and enteritis (pneumoenteritis).
- Sheep: treatment of animals with necrobacillus, as well as respiratory diseases.
- Pigs: treatment of animals with enzootic pneumonia, dysentery, enteritis, arthritis, swine fever and secondary bacterial infections in viral diseases.
- Dogs: treatment of animals with diseases of the respiratory system, skin and genitourinary system (such as pneumonia, pharyngitis, laryngitis, bronchitis, pyoderma, dermatitis, abscesses, cystitis, metritis).
- Cats: treatment of animals with diseases of the respiratory system, genitourinary system, abscesses and infected wounds, secondary bacterial infections with viral diseases (panleukopenia, pneumonia, rhinotracheitis).
- Poultry (chickens, turkeys): treatment of poultry suffering from alveolar sac infection, cholera, staphylococcal infection, sinusitis and acute rhinitis, as well as respiratory diseases.
Dosage
Intramuscularly in a dose:
- calves: 1 ml of the drug per 10 kg of body weight 2 times a day on the first day of treatment and 1 time a day for the next 2-4 days;
- sheep and goats: 1 ml of the drug per 10 kg of body weight once a day for 3 days;
- pigs: 1 ml of the drug per 10 kg of body weight once a day for 3-7 days;
- dogs and cats: 1 ml of the drug per 5 kg of body weight.Β The drug is administered every 12-24 hours.Β The course of treatment can last up to 21 days.
Subcutaneously in a dose: poultry (chickens, turkeys): 0.5 ml of the drug per 2.5 kg of body weight 1 time per day for 3 days.
*Kilograms to a Pounds conversion table
| Kilograms (kg) | Pounds (lb) | Pounds+Ounces (lb+oz) |
| 0.1 kg | 0.220 lb | 0 lb 3.527 oz |
| 1 kg | 2.205 lb | 2 lb 3.274 oz |
| 5 kg | 11.023 lb | 11 lb 0.370 oz |
| 10 kg | 22.046 lb | 22 lb 0.740 oz |
Contraindication
Do not use in animals with hypersensitivity to lincomycin and spectinomycin.
Do not use in pregnant animals.Β Do not inject to rabbits, horses, ants, as well as laying hens, whose eggs are used for human consumption.
Do not use simultaneously with penicillin, cephalosporins and macrolides.
Withdrawal period
Slaughter of animals and poultry for meat is allowed after 15 (sheep, goats and poultry) and 21 (calves, pigs) days, respectively, after the last application of the drug.Β The meat obtained before this deadline is disposed of or fed to unproductive animals, depending on the opinion of the veterinarian.
Storage
In a dry dark place, out of reach of children, at a temperature of + 8 Β° C to + 15 Β° C.
After the first withdrawal from the vial, the drug should be used within 28 days if stored at a temperature of + 0 Β° C to + 5 Β° C.
Shelf lifeΒ 2 years.
