Enrofloxacin 100 mg/ml Solution for injection
Storage
1 ml of the drug contains:
enrofloxacin – 100 mg
Description
The liquid is yellow or light brown, homogeneous, transparent.
Pharmacological properties
Enrofloxacin belongs to the group of fluoroquinolones and has a wide range of antibacterial action. Inhibits the growth and development of gram-positive and gram-negative bacteria – Staphylococcus aureus, Streptococcus spp., Clostridium perfringens, Corynebacterium spp., Escherichia coli, Haemophilus spp., Salmonella spp., Pastrurella spp., Camellosa snas., Pseudomonas s. spp., as well as Mollicutes spp.
The mechanism of action is to inhibit the activity of the enzyme DNA gyrase, which affects the replication of the DNA helix in the nucleus of a bacterial cell.
When administered parenterally, it is rapidly absorbed from the injection site and penetrates into all organs and tissues of the body. The maximum concentration in the blood is observed after 20-40 minutes, the therapeutic concentration is maintained for 24 hours. The concentration in the affected tissue is higher than in healthy.
Excreted mainly unchanged, partially metabolized to ciprofloxacin and excreted in urine and feces. Does not cause nephrotoxic effect.
Indication
Treatment of cattle and pigs for diseases of the gastrointestinal tract, respiratory system, urogenital system, as well as septicemia, colibacillosis, salmonellosis, streptococcus, bacterial and enzootic pneumonia, atrophic rhinitis, MMA syndrome (mastitis-metritis-chorgachi, agalactis) to enrofloxacin, in bacterial complications of viral diseases.
Method of application and dosage
1 kilogram (kg) is equal to 2.20 pounds (lbs).1 kg = 2.20 lb
Before use, the drug is thoroughly shaken and administered once a day in the following doses:
- cattle – 0.25-0.5 ml per 10 kg of body weight, subcutaneously, course – 5 days;
- pigs – 0.25 ml per 10 kg of body weight, intramuscularly, the course – 3-5 days.
Injections larger than the following values are divided into several parts and injected in different places to prevent pain:
- calves sows – 5 ml;
- pigs – 2.5 ml.
Reservation
When using the drug in the recommended doses, side effects and complications are usually not observed. Occasionally there may be short-term gastrointestinal dysfunction, and in pigs – irritation at the injection site.
After the last application of the drug, slaughter of animals for meat is allowed in 10 days, people can eat milk in 7 days. Meat and milk obtained earlier than this period are disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.
Due to the possible development of resistant strains of microorganisms, the drug should not be used in infections of moderate severity.
The drug should be used only after receiving the results of the test for susceptibility of microorganisms to enrofloxacin.
Contraindication
Do not prescribe to animals with hypersensitivity to the active substance of the drug, with clinical signs of diseases of the CNS, musculoskeletal system and damage to articular cartilage, in the detection of resistant strains of pathogenic bacteria resistant to quinolones.
Do not use in pregnant sows or horses, do not use for prophylaxis.
Do not use simultaneously with theophylline, caffeine and antipyrine.
Storage conditions
In a dry, dark place, out of reach of children at a temperature of +5 to +25 ° C.
After opening the vial, store the drug in the refrigerator and use for 30 days.
Expiration date
2 years.
