Enroflox 5% (enrofloxacin 50 mg) Solution for Injection, Baytril analogue

Description

A clear solution of pale yellow or yellow color.

Storage

1 ml of the drug contains the active substance:

enrofloxacin 50 mg.

Excipients: potassium hydroxide, benzyl alcohol, citric acid monohydrate, water for injections.

Pharmacological properties

Enrofloxacin belongs to the group of fluoroquinolones. The mechanism of its bactericidal action is associated with the inhibition of the subunit A of DNA hydrase (topoisomerase II) of the bacterium, which blocks the process of supercoiling of the DNA molecule. In gram-positive bacteria, this process affects topoisomerase IV rather than topoisomerase II. This blocks the reproduction, transcription, and recombination processes in the DNA of the bacterium.

The drug is effective against gram-negative and gram-positive microorganisms: E. coli, Salmonella spp., Klebsiella spp., Haemophilus spp., Pasterella spp., Clostridia spp., Bordetella spp., Streptococcus spp., Staphylococcus sppne. and others, and also acts on mycoplasmas (Mycoplasma spp.).

Application

Calves: treatment of animals with respiratory diseases (bronchopneumonia, hemorrhagic septicemia, mycoplasmosis), digestive tract (colibacillosis and others) caused by microorganisms sensitive to enrofloxacin.

Pigs: treatment of animals with diarrhea, enterotoxemia, MMA syndrome (metritis-mastitis-agalactia) caused by microorganisms sensitive to enrofloxacin.

Dogs: treatment of animals with diseases of the digestive tract, respiratory system, and urogenital system, as well as skin caused by microorganisms sensitive to enrofloxacin.

Dosage

Subcutaneously in a dose:

calves – 0.5 – 1 ml of the drug (2.5 – 5.0 mg of enrofloxacin per kg of bodyweight of the animal) per 10 kg of body weight once a day for 3 days. In the treatment of salmonellosis or severe infections, the drug is used for 5 days. Do not inject more than 10 ml at a single injection site;

dogs – 0.1 ml of the drug (5.0 mg of enrofloxacin per kg of bodyweight of the animal) per I kg of body weight once a day for 5 days.

Intramuscularly in a dose:

pigs – 0.5 – 1 ml of the drug (2.5 – 5.0 mg of enrofloxacin per kg of bodyweight of the animal) per 10 kg of body weight once a day for 3 days. In the treatment of salmonellosis or severe infections, the drug is used for 5 days. Do not inject more than 2.5 ml into a single injection site.

Contraindication

Hypersensitivity to enrofloxacin.

Do not use in dogs of small and medium breeds in the first 12 months of life, and dogs of large breeds – in the first 18 months of life, pregnant bitches and bitches during lactation. Do not treat animals with signs of central nervous system disease. Do not use in animals with insufficient development of cartilage and bone tissue. Do not use in pregnant or lactating animals. Do not use simultaneously with tetracycline drugs, macrolides (erythromycin), chloramphenicol, theophylline.

Do not use in the detection of quinolone-resistant strains of pathogenic bacteria.

Reservation

Slaughter of animals and poultry for meat is allowed 14 days after the last application of the drug. The meat obtained before this date is disposed of or fed to unproductive animals, depending on the opinion of the veterinarian.

Release form

Bottles made of yellow glass, closed with a rubber stopper under an aluminum run-in of 100 ml.

Storage

Dry, dark, inaccessible to children at a temperature of 5 ° to 25 ° C.

Shelf life – 3 years.

For use in veterinary medicine!