Sarafloxacin – 10g, powder for oral use

Description
Powder white or light yellow dissolves water.
Storage
1 g of the drug contains: sarafloxacin hydrochloride 100 mg.
Pharmacological properties
The antibacterial broad-spectrum drug.
Sarafloxacin Antibiotics fluoroquinolones, mechanism of action is caused by the inhibition of the activity of DNA gyrase (topoisomerase II types of gram-negative bacteria and topoisomerase IV type in certain Gram-positive bacteria) that provide replication of DNA in the nuclei of microbial cells and their subsequent separation, resulting in bacteria multiply.
Effective against gram-positive and gram-negative microorganisms, including resistance to beta-lactam antibiotics, tetracyclines, aminoglycosides and macrolides: E. coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Staphylococcus aureus, Streptococcus spp., Mycoplasma spp., Campylobacter spp., Klebsiella spp., Bordetella spp., Clostridium spp., Yersinia spp., Pseudomonas spp., Enterobacter spp., Ornithobacterium spp. others.
Sarafloxacin is one of the major programs in the treatment of poultry colibacillosis and salmonellosis. It is twice as active against gram-positive bacteria and is four times more active against gram-negative microorganisms than norfloxacin and active against anaerobes for ciprofloxacin.

Rapidly absorbed from the gastrointestinal tract into the bloodstream and penetrate all organs and tissues. Bioavailability of broilers oral use is 59,6; 13,8%. The maximum blood concentration is reached in 1.5-3 hours after application. In the liver, poultry sarafloxacin in small quantities and sulfamic metabolized to compounds hlyukoronidnyh. The biological half-life of 30.13 hours. Write mainly with feces and kidneys mostly unchanged.
Indication
Treatment of birds (chickens, broilers, Heifer, chickens, chicks, turkeys) for diseases in colibacillosis, salmonellosis, necrotic enteritis, septicemia, stafilokokoz, streptococci, mycoplasmosis, hemofiloz, pasteurellosis, secondary bacterial infections in viral diseases as well as diseases of the respiratory system, gastrointestinal tract, urinary tract, caused by pathogens susceptible to sarafloxacin.
Contraindication
Do not administer to animals with hypersensitivity to sarafloxacin. Do not use poultry eggs which eat people. Do not use it together with theophylline, caffeine, chloramphenicol, thiamphenicol, fluorfenikolom.
Dosage and Administration
Before applying powder dissolved in water and given orally at a dose of 0.5 g product per 10 kg, course 3 days. The course of salmonellosis can be extended up to 4-5 days.
Depending on the daily requirement of water intake dose is 25-50 grams per 100 liters.
During treatment, the bird has only received drinking water containing the drug.
Reservation
When using the drug in recommended doses side effects complications were observed.
Drinking with the preparation for birds is placed in protected areas from the sun.
After the last use of the drug culling of poultry meat is permitted after 4 days. M meat received before the deadline, or utilize unproductive animals fed depending on the opinion of a veterinarian.
Packaging
Polymer packs and containers 10, 500 g
Storage conditions
In a dry, dark place at a temperature of +8 to + 15 C.
After opening the container drug store in the refrigerator and use within 30 days, an aqueous solution of the drug for 24 hours.
Expiration date
2 years.