Simparica Trio Chewable for Dogs 5,1-10 kg (11.1-22 lbs) | 3 tablets

Description

Reddish-brown pentagonal tablets with rounded edges. The tablets are embossed on one side, which indicates the amount of sarolaner in the tablet.

Composition

100 mg of the drug contains active substances:

• sarolaner – 1.333 mg
• moxidectin – 0.027 mg
• pyrantel (as pyrantel embonate) – 16.013 mg.

Excipients: hypromellose, lactose monohydrate, starch glycolate type A, meglumine, butylhydroxytoluene (E321), pigment mixture 018 (E110, E129, E132), hydroxypropylcellulose, silicon, colloidal sugar, anhydrous colloidal anhydrous pork liver powder, hydrolyzed vegetable protein, gelatin, wheat germ, anhydrous calcium hydrogen phosphate.

Pharmacological properties

ATCvet QP54AB52, antiparasitic products, moxidectin combinations.

Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. The main object of action of sarolaner in insects and acarids is the functional blockade of ligand-dependent chloride channels (GABA receptors and glutamate receptors). Sarolaner blocks GABA and glutamate-dependent chloride channels in the central nervous system of insects and acarids. Disruption of these receptors by Sarolaner prevents the absorption of chlorine ions by GABA and glutamate-dependent ion channels, which leads to increased nerve stimulation and death of the target parasite. Sarolaner demonstrates a higher functional ability to block insect / acarid receptors than mammalian receptors. Sarolaner does not interact with known insecticidal binding sites of nicotine or other GABAergic insecticides, such as neonicotinoids, fiproles, milbemycins, avermectins and cyclodienes.

After application of the drug, the lethal effect on ticks that parasitize the animal and new invasions begins within 48 hours.

For fleas, the onset of effective action of the drug occurs 12-24 hours after application and lasts 5 weeks. Fleas that have already parasitized the animal die 8 hours after application of the drug. The veterinary drug kills new fleas on the dog before they can lay eggs, and therefore it prevents flea contamination of the environment in places where the dog has access.

Moxidectin is a second-generation macrocyclic lactone of the milbemycin group. Its main mode of action is interference in neuromuscular transmission at the level of glutamate-dependent chloride channels and, to a lesser extent, GABA (gamma-aminobutyric acid) – dependent channels. This interference leads to the opening of chloride channels on the postsynaptic junction to ensure the influx of chloride ions. This leads to paralysis and death of parasites affected by the drug. Moxidectin is active against adults Toxocara canis, larvae L4 and immature stages (L5) Ancylostoma caninum, L4 Dirofilaria immitis and immature stages (L5) Angiostrongylus vasorum.

Pyrantel is a nicotinic acetylcholine (ACh) channel receptor (nAChR) agonist. Pyrantel mimics the agonistic effects of ACh due to high-affinity binding to subtype-specific ionophore nAChR in nematodes, without binding to muscarinic nAChR. After binding to the receptor, the channel opens to allow the influx of cations, which leads to depolarization and excitatory effects on the muscles of the nematode, which ultimately leads to spastic paralysis of the parasite and death. Pyrantel is active against immature stages (L5) and adults Toxocara canis, adults Ancylostoma caninum, Toxascaris leonina and Uncinaria stenocephala.

In this fixed combination, moxidectin and pyrantel provide additional anthelmintic efficacy due to different mechanisms of action. In particular, both active substances contribute to the overall effectiveness against gastrointestinal nematodes Ancylostoma caninum and Toxocara canis.

Sarolaner is easily and rapidly absorbed systemically after oral administration, reaching a maximum concentration in blood plasma within 3.5 hours (maximum time) after administration with a high bioavailability of 86.7%. Sarolaner is slowly excreted from the blood plasma (half-life is approximately 12 days) due to biliary excretion and faecal excretion with a small contribution to metabolic clearance.

Moxidectin is easily and rapidly absorbed systemically after oral administration, reaching maximum plasma concentrations within 2.4 hours (maximum time) after administration and with 66.9% bioavailability. Moxidectin is slowly excreted from the blood plasma (half-life is approximately 11 days) due to biliary excretion and excretion in the faeces with a small contribution to metabolic clearance.

Pyrantel embonate is poorly absorbed, and the absorbed part has a maximum time of 1.5 hours and a half-life of 7.7 hours. Pyrantel is excreted in the feces, and a small absorbed part is excreted mainly in the urine.

The condition of dogs after eating does not affect the degree of absorption of sarolaner and moxidectin.

Application

Use in dogs that have mixed invasions of external and internal parasites, or are at increased risk of infection. Simparica Trio is used against animals against ticks, fleas and gastrointestinal nematodes detected simultaneously. The drug is also used to prevent heartworm disease (Dirofilaria spp.) And angiostrongylus vasorum.

Ectoparasites

• For the treatment of ixodidosis. The drug immediately and permanently kills Ixodes spp and Rhipicephalus sanguineus for 5 weeks, as well as for 4 weeks against Dermacentor reticulatus.
• For the treatment of ktenocephaly. The drug immediately and permanently destroys and protects against new lesions for 5 weeks from the species Ctenocephalides felis and Ctenocephalides canis.
• The drug can be used as part of a therapeutic strategy for the treatment of allergic dermatitis caused by fleas (FAD).

Gastrointestinal nematodes

For the treatment of nematodes of the gastrointestinal tract and respiratory tract:

• Toxocara canis (larval, young and mature stages);
• Larvae of Ancylostoma caninum L4 and L5, young and mature stages;
• Toxascaris Ieopipa puberty;
• Uncinaria stenocephala mature stages.

Other nematodes

• For the prevention of heartworm disease (Dirofilaria immitis);
• For the prevention of angiostrongylus (Angiostrongylus vasorum) by reducing the level of infection with larvae (L3) and adult stages.

Dosage

The drug is intended for oral use. The dog can take the pill with or without food.

Simparica Trio tablets taste good and are readily consumed by most dogs when offered by the owner. If the pill is not taken by the dog voluntarily, it can also be given with food or directly into the mouth. The tablets should not be divided.

The drug should be administered at a dose of 1.2-2.4 mg / kg sarolaner, 0.024-0.048 mg / kg moxidectin and 5-10 mg / kg pyrantel according to the following table:

Treatment schedule

The schedule of treatment should be based on the diagnosis of the veterinarian, the local epidemiological situation and / or the epidemiological situation in other areas that the dog has visited or is going to visit. If based on the conclusion of the veterinarian requires re-administration of the drug, then all subsequent treatments are carried out with an interval of at least 1 month.

The drug should be used only in dogs, when simultaneously shown treatment of the animal from ticks / fleas and gastrointestinal nematodes. In the absence of risk of mixed co-invasion, a parasiticide with a narrower spectrum of action should be used.

Treatment of animals for flea and tick infestations and gastrointestinal nematodes:

The veterinary drug can be used as part of the seasonal treatment of animals against fleas and ticks (replacement of treatment with monoactive fleas and ticks) in dogs diagnosed with concomitant gastrointestinal nematodes. One-time treatment is effective for the treatment of gastrointestinal nematodes. After treatment of nematode infestations, subsequent treatment of the animal against fleas and ticks should be continued with a monoactive drug.

Prevention of heartworm disease and angiostrongylosis:

A single injection also prevents pulmonary nematodes (reducing the number of immature adults (L5) A. vasorum) and heartworm disease (D. immitis) for one month. When Simparica Tiro replaces another drug for the prevention of pulmonary or cardiac nematodes, the first dose should be administered within one month after the last dose of the previous veterinary medicinal product. In endemic areas, dogs should receive prophylactic treatments against pulmonary and / or cardiac nematodes at monthly intervals. It is recommended to continue the prevention of heartworm disease for at least 1 month after the last contact with mosquitoes.

Contraindication

Do not use in case of hypersensitivity to active substances or excipients.

Reservation

Ticks and fleas must begin to feed on the host so that the sarolaner can act on them; therefore, the transmission of infectious diseases caused by parasites cannot be ruled out.

This veterinary drug is not effective against the adult stage of D. immitis. However, accidental administration to dogs infected with adult cardiac nematodes should not pose a safety concern. Dogs in areas endemic for heart nematodes (or those that have traveled to endemic areas) may be infected with adult heart nematodes. Maintaining the effectiveness of macrocyclic lactones is crucial to control Dirofilaria immitis. To minimize the risk of selective resistance, it is recommended that dogs be tested for both circulating antigens and microfilariae in the blood at the beginning of each preventive treatment season. Only negative animals should be treated.

Resistance of parasites to any particular class of parasiticides may develop after frequent or repeated use of a product of this class. Therefore, the use of this drug should be based on a case-by-case assessment and local epidemiological information on the current susceptibility of the target species to limit the possibility of future selective resistance.

Special precautions for use in animals

Treatment of puppies less than 8 weeks of age and / or dogs weighing less than 1.25 kg should be based on an assessment of the benefits and risks by a veterinarian.

The drug was well tolerated in dogs with mutations in the ABC1 gene (MDR1 – / -). However, in such sensitive breeds (collies, related breeds and other sensitive dogs) should strictly adhere to the recommended dosage.

Special precautions for persons administering veterinary medicinal products to animals

Wash hands after contact with product.

Accidental ingestion of the product can potentially lead to side effects such as transient excitatory neurological signs. To prevent children from accessing the product, only one chewable tablet should be removed from the blister pack at a time and only as needed. Then the blister should be returned to the cardboard box immediately after use, the box should be stored out of reach of children. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

Use during pregnancy or lactation

The safety of the drug has not been studied in pregnancy and lactation, or in animals intended for breeding. Use in such creatures is not recommended.

Adverse reactions

Not known.

Release form

The drug is available in tablets, which are packed in aluminum blisters.

Secondary packaging – cardboard boxes containing a blister with three tablets.

Storage

Dry place at a temperature not exceeding 30 ° C.

Do not freeze!

Remove the tablet from the blister just before use.

Shelf life – 30 months.

For use in veterinary medicine!