Ceftio (ceftiofur) powder for injection (NAXCEL ANALOG), 4 g

A third-generation antibiotic from the group of cephalosporins with a broad spectrum of bactericidal action. The mechanism of action is to inhibit the synthesis of the cell wall of bacteria.

1 vial of the drug contains:

ceftiofur sodium salt

Description

White or light brown powder.

Pharmacological properties

A third-generation antibiotic from the group of cephalosporins with a broad spectrum of bactericidal action against gram-positive Streptococcus zooepidemicus, S. suis, Actinomyces pyogenes, Staphylococcus spp., Bacillus spp. and gram-negative Pasteurella (Mannheimia) haemolytica, P. multocida, Haemophilus somnus, H. parasuis, Actinobacillus pleuropneumoniae, Escherichia coli, Salmonella choleraesuis, S. typhimurium, Fusobacterium necrophori, Sc. Proteus spp. microorganisms, including anaerobes and species that produce beta-lactamase. The mechanism of action is to inhibit the synthesis of the cell wall of bacteria.

After parenteral administration, it is rapidly metabolized to form desfuroylceftiofur, which has a similar bactericidal effect, unstable binding to plasma proteins and accumulates in the affected areas of tissues, without reducing its activity, even in necrotized tissues.

After parenteral administration, it is rapidly absorbed and penetrates into all tissues of the body. Its maximum concentration in blood plasma is reached in one hour and remains at a therapeutic level for up to 24 hours. In cows, the maximum concentration in plasma is observed in 1.5-2 hours, and in the mucous membrane of the uterus, carbuncles and lochia – in 3-7 hours after administration. The antibiotic and its metabolites are excreted mainly in the urine (55-70%) and feces (approximately 30%).

Method of application and dosage

Before using the drug, the contents of the vial 0.5, 1 or 4 g are diluted in 10, 20 or 80 ml of sterile water for injection, which is pre-warmed to room temperature (1 ml of the resulting solution contains 50 mg of ceftiofur). The drug is dissolved in accordance with the rules of asepsis as soon as possible, shaking thoroughly to a homogeneous solution, and administered subcutaneously in the following doses:

• respiratory diseases – 0.6 ml per 10 kg of body weight (3.3 mg of ceftiofur per 1 kg of body weight), course – 5 days;
• skin diseases – 0.4-0.8 ml per 10 kg of body weight (2.2-4.4 mg of ceftiofur per 1 kg of body weight), course – 8-10 days;
• diseases of the urinary tract, purulent wounds, polyarthritis – 0.8 ml per 10 kg of body weight (4.4 mg of ceftiofur per 1 kg of body weight), course – 8-10 days.

*Kilograms to Pounds conversion table

Reservation

When used in the recommended doses, no side effects are observed. There may be a temporary pain reaction at the injection site.

There are no restrictions on use during pregnancy and lactation.

Indication

Treatment of dogs with polyarthritis, diseases of the respiratory system, urinary tract and skin caused by Escherichia coli and Proteus mirabilis.

Contraindication

Do not use in animals with hypersensitivity to ceftiofur and other lactam antibiotics.

Storage conditions

In a dry, dark place, out of reach of children at a temperature of +2 to +8 ° C.

The drug solution should be stored at a temperature of +20 to +25 ° C for no more than 12 hours, at a temperature of +2 to +8 ° C – 7 days.

Expiration date

2 years.

Bronchitis; Colibacteriosis; Necrobacteriosis; Pasteurellosis; Pneumonia; Rhinitis; Sepsis; Staphylococci; Tracheitis; Enteritis