Brovnol-C syringe (praziquantel, pyrantel) Dewormer for Dogs and Cats, 15 g

Storage

1 g of the drug contains:

praziquantel — 15 mg

pyrantel pamoate — 45 mg

Description

Light yellow liquid.

Pharmacological properties

Combined anthelmintic preparation of a wide spectrum of action against round and tapeworms at all stages of development parasitizing dogs and cats — Toxocara canis, Toxocara mistax, Toxascaris leonina, Uncinaria spp., Trichuris vulpis, Ancylostoma spp., Echinococcus granulosus, Alveococus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobothrium latum, Multiceps multiceps, Taenia spp.

Praziquantel is a synthetic compound derived from quinoline. The mechanism of action is based on the violation of the permeability of cell membranes of helminths for calcium ions, which leads to inhibition of glucose metabolism, destruction of cell membranes in parasites and their rapid paralysis. This causes the death of parasites and their removal from the gastrointestinal tract.

Praziquantel is well absorbed in the gastrointestinal tract and reaches the maximum concentration in blood plasma after 1-3 hours, its bioavailability is about 80%. It is distributed among the organs and tissues of the body and binds to blood proteins by 70-80%. It is metabolized in the liver with the formation of inactive metabolites, excreted from the body with urine, a small amount with feces. The elimination half-life is about 1.5 hours.

Pyrantel pamoate is a tetrahydropyrimidine derivative. Active against nematodes of all forms of development. Blocks the transmission of nerve impulses in neuromuscular synapses by depolarizing muscle cell membranes, thereby causing paralysis of the nematode muscle system.

It is almost not absorbed from the intestines, due to which its anthelmintic effect is prolonged. It is excreted from the body mainly unchanged (up to 93%) with feces.

Indication

Treatment and prevention of nematodes (toxocarosis, toxascariasis, uncinariasis, trichocephalosis, hookworm), cestodes (taeniidosis, dipilidiosis, echinococcosis, diphyllobotriosis, mesocestoidosis) and mixed nematodes and cestodes infestations in dogs and cats .

Contraindication

Do not prescribe to animals with increased sensitivity to the active substances of the drug, females in the first half of pregnancy and within two weeks after giving birth, puppies and kittens under 3 weeks of age, exhausted animals and animals with infectious diseases.

Method of application and dosage

Before use, the suspension is shaken and given before morning feeding individually, once, with a small amount of food or forcibly on the root of the tongue using a syringe.

The dose is 0.5 ml per 1 kg of body weight, for small animals – 0.33 ml per 1 kg of body weight. In case of severe infestation, the treatment is repeated after 10 days.

Preventive deworming is carried out quarterly, as well as before vaccination – 12-14 days in advance.

It is not necessary to use a fasting diet or laxatives before the introduction of the drug.

Reservation

In some animals, with a strong infestation, complications are possible due to intoxication during the digestion of dead helminths – urticaria, itching in the anus, anxiety, diarrhea, sometimes vomiting. These symptoms disappear without special treatment.

Storage conditions

In a dry, dark place inaccessible to children, separate from food products and fodder at temperatures from +4 to +25 °C.

After the first selection, store the drug in the refrigerator and use it within 30 days.

Expiration date

2 years.

TYPES OF HELMINTHIASIS

Helminth infections are perhaps the most common parasitic diseases of dogs and cats.

Helminths affecting pets are divided into 3 groups: tapeworms, roundworms and flatworms. All of them cause intoxication, digestive disorders and harm internal organs. These parasitic worms absorb vitamins, minerals and other useful substances from the body. Puppies and kittens suffer the most from this.

On the territory of Ukraine (as in the whole of Europe), helminths of the following species are dangerous for dogs and cats: nematodes (roundworms), cestodes (tapeworms) and trematodes (flatworms or suckers).

Signs of helminth damage:

• periodic vomiting;
• constipation (constipation) alternates with diarrhea (diarrhea);
• sudden weight loss of the animal;
• the animal becomes less energetic, the fur fades, itches under the tail;
• Puppies and kittens may have a distended belly and protruding ribs at the same time.

Five steps to protect your pet from infection

1. Do not allow to lick and eat something from the ground, quench your thirst with water from a puddle or reservoir.
2. Water and food must be clean.
3. Wash paw pads thoroughly after walks.
4. Treat animals regularly against fleas and ticks, as fleas carry the eggs of some helminths (dipylidia).
5. Carry out preventive deworming.

How often to carry out deworming?

Deworming, known among pet owners as deworming, should become a regular routine. Veterinary medicine doctors recommend deworming once every three months.

But sometimes extra-ordinary deworming is needed:

• animals that eat raw offal, meat, fish;
• hunting dogs and animals living outside;
• before mating, vaccination or moving;
• when adult forms of parasites are detected in feces, a bloated tummy, the appearance of vomiting, diarrhea, etc.

If parasitosis is suspected, angelmintics are given again in the same dose after 10-14 days. Because most drugs against worms act only on adult parasites (imaginal forms). But after 10 days, the eggs of worms that remained intact mature. These are the ones that should be destroyed by repeated use of the drug.

Correct deworming in questions and answers

QUESTION #1. WHEN TO CARRY OUT THE FIRST DEWORMING?

Anthelmintic drugs are needed by your pets from the first weeks of life. And it is better to carry out the first processing at the age of 3 weeks.

QUESTION #2. HOW OFTEN TO USE DEWORMING PILLS FOR DOGS AND CATS?

After the first treatment, the drug is given 2-3 more times with an interval of 7-14 days. This is related to the development cycle of parasitic worms (see How often to deworm?).

QUESTION #3. WHAT FORMS OF DRUGS SHOULD BE PREFERRED?

Drugs against worms for dogs and cats are produced in different forms. You can choose from them, taking into account the preferences of your pet or the ease/convenience of using the tool.

It is easier to give medicine orally in the form of syrup or suspension to dogs of miniature breeds, puppies and cats. It is convenient to use pipettes or syringes for accurate dosing of such agents. Many preparations have an attractive taste for dogs and cats. If this is not the case, the tablet can be mixed with wet feed and be sure to make sure that the animal eats everything together with the drug.

QUESTION #4. WHAT IS IMPORTANT TO DO BEFORE DEWORMING?

Weigh the pet, because the dose of the drug always depends on the weight of the animal.

QUESTION #5. HOW TO CARRY OUT TREATMENT IF SEVERAL ANIMALS LIVE TOGETHER?

In this case, preparations from worms should be given to everyone. In this case, preparations from worms should be given to everyone.

QUESTION #6. IS IT BETTER TO CHANGE ANTHELMINTICS OR USE THE SAME ONE?

No matter how much you or your pet likes an antiparasitic, it’s best to use a different one each time. Drug rotation is necessary to prevent parasites from developing resistance to the active ingredients of the anthelmintic.

Brovapharma’s portfolio includes products from the Brovanol series, which contain various active substances. These drugs allow you to get rid of parasites without developing resistance in them:

• Brovanol-C — suspension in syringe-tubes with a dispenser for young animals;
• Brovanol M is a tablet for small breed dogs, cats and young animals;
• Brovanol D, Brovanol Plus is a tablet for large breed dogs.

ARE ANTHELMINTICS SAFE FOR ANIMALS?

The active substances of anthelmintic drugs (praziquantel, fenbendazole, albendazole, piperazine, ivermectin, pyrantel, etc.) are essentially poisons, but in the doses indicated by the manufacturer, they are safe for the health of pets. Even a tenfold dose will not harm the animal, but we recommend one thing:

• strictly follow the dosage and recommendations specified in the leaflet;
• do not deworm weak, sick, exhausted, weakened animals (for example, after surgery), because this can cause complications.

It is worth noting that Brovanol-C produced by “Brovafarm” (suspension in a dosing syringe based on praziquantel and pyrantel pamoate) is not absorbed in the intestines, but acts directly on helminths. Therefore, the drug is safe for puppies and kittens, pregnant females, as it does not cause a systemic effect on the body. The new release form of Brovanol-C allows you to dose the product as accurately as possible.

IS IT WORTH WORMING ANIMALS THAT DO NOT GO OUTSIDE?

If your pet never leaves the apartment, this does not mean that he cannot be infected with helminths. To catch a parasite, the animal does not necessarily have to walk. Most animals are infected in early childhood, from a mother that was not treated before mating. In addition, owners often bring helminth eggs on their shoes. In addition, there is a risk of infection through meat if the animal consumes it. Therefore, preventive deworming is necessary for everyone.

Animals that are not on the street are dewormed according to the general scheme: once a quarter under the age of 1 year and once every six months over the age of 1 year.

WHY DO VETERINARIANS INSIST ON DEWORMING AN ANIMAL BEFORE VACCINATION?

Animal vaccination is one of the most important stages of the artificial formation of immunity against dangerous infectious diseases (carnivore plague, parvovirus, feline panleukopenia, calicivirus, etc.). By vaccinating an animal, we introduce weakened viruses — the causative agents of these diseases — into the body in order to induce the formation of immunity. However, if a parasite interferes with this process, immunity may be weak and short-lived. Therefore, veterinarians recommend deworming 10-14 days before vaccination.

IS IT POSSIBLE TO GIVE ANGELMINTS TO PREGNANT AND LACTATING ANIMALS?

The leaflet for most drugs states that deworming is not recommended for lactating and pregnant females. This is explained by the fact that the drug, being absorbed into the blood, can cause an embryotoxic effect or get into the milk that is fed to the cubs. Therefore, most producers insist that deworming be carried out 10-14 days before the expected mating.

However, some drugs, such as Brovanol-C, allow deworming of pregnant and lactating animals, since their active substances are not absorbed from the intestines, but act locally.