Solution sulfamethazine + trimethoprim Zpril (Sulmet)

The solution is yellowish.

Composition
1 ml of the preparation contains active ingredients:

sulfamethazine – 200 mg
trimethoprim – 40 mg.
Excipients: citric acid, sodium pyrosulfite, hydrochloric acid, sodium hydroxide, sodium methyl p-hydroxybenzonate, sodium propyl p-hydroxybenzonate, water for injection.

Pharmacological properties
Sulfamethazine is a synthetic chemotherapeutic agent from the sulfamide group. Trimethoprim is a synthetic chemotherapeutic agent derived from diaminopyrimidine.

Separately, each component has a bacteriostatic mechanism, but sulfamethazine and trimethoprim, taken in a 4: 1 ratio, enhance the effect of the drug and give it a bactericidal nature of action.

Such synergy is manifested due to the fact that its components affect two sequential processes that are necessary for the synthesis of tetrahydrofolic acid or bacterial folic acid, which plays a major role in the synthesis of bacterial purines. The bacterial wall is impermeable to folates, so the synthesis of purines depends on the intrinsic synthesizing ability of microorganisms.

These two components work as follows:

sulfamethazine, in its chemical characteristics, is similar to p-aminobenzoic acid, and together with it participates in the formation of the enzyme dihydropteroyl synthetase, counteracting the formation of dihydrofolic acid;
Trimethoprim blocks the next link in the biosynthetic chain, inhibiting the action of dihydrofolate reductase, an enzyme that accelerates the conversion of dihydrofolic acid to tetrahydrofolic acid.
The combination of these chemotherapeutic components gives the drug a bactericidal effect. At the same time, the appearance of microbial strains resistant to the drug is insignificant.

The combination of sulfamethazine-trimethoprim has a broad spectrum of action, including gram-positive and gram-negative bacteria. Microorganisms that are very sensitive to the action of the drug include the following bacteria: Escherichia coli, Clostridium spp., Shigella spp., Salmonella spp., Proteus mirabilis, Bacillus anthracis, Pasteurella spp., Haemophilus influenzae, Haemophilus gallinarum and Vibrio spp. Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus viridans, Streptococcus agalactiae, Staphylococcus aureus, Proteus spp. and Brucella spp.

Application
Cattle: treatment of animals suffering from colibacillosis and salmonella gastroenteritis, vibriosis, pneumonia, septicemia, pasteurellosis, coccidiosis and colibacillosis mastitis, actinomycosis, purulent abscess, as well as diseases of the genitourinary system caused by sulphimetasis and sulphimetasis-sensitive microorganisms.

Horses: treatment of animals with diarrhea, pneumonia, pyosepticemia caused by microorganisms sensitive to sulfametazim and trimethoprim.

Pigs: treatment of animals suffering from colibacillosis, salmonellosis, vibrious dysentery, pneumonia, pasteurellosis, malignant edema, abscesses caused by microorganisms sensitive to sulfametazim and trimethoprim.

Sheep: treatment of animals suffering from colibacillosis, salmonellosis, vibrious dysentery, pneumonia, enteritis, abscesses and mastitis caused by microorganisms sensitive to sulfametazim and trimethoprim.

Dogs, cats: treatment of animals suffering from pulmonary infections, septicemia, bacterial enteritis, coccidiosis in dogs caused by microorganisms sensitive to sulfametazim and trimethoprim.

Dosage
Intramuscularly at a dose of 1 ml per 10 kg of body weight of the animal daily for 3-5 days. The first day of treatment, the daily dose is divided into two parts and administered at intervals of 12 hours.

Contraindications
Hypersensitivity to sulfonamides. Do not administer to animals with renal or hepatic impairment. Do not use in conjunction with folates and p-aminobenzoic drugs.

Warning
Slaughter of animals for meat is allowed 28 days after the last use of the drug. The consumption of milk for human consumption is allowed 4 days after the last use of the drug. The meat and milk received before the specified period is disposed of or fed to unproductive animals, depending on the conclusion of a veterinary doctor.

Release form
Bottles made of transparent brown hydrolytic glass, closed with a rubber stopper for aluminum rinsing, 100 ml each. Secondary packaging – cardboard box.

Storage
A dry, dark place out of the reach of children at a temperature of 5 ° to 25 ° C.

The shelf life is 5 years.

For use in veterinary medicine!