Enroxil 5% injection (enrofloxacin 50 mg)
Description
Clear solution from yellow to light brown with almost no inclusions.
Storage
1 ml of the drug contains the active substance:
enrofloxacin – 50 mg.
Excipients: n-butanol, potassium hydroxide, water for injections.
Pharmacological properties
PBX vet classification code QJ01 – antibacterial veterinary drugs for systemic use. QJ01MA90 – Enrofloxacin.
Enrofloxacin belongs to the group of fluoroquinolones. It is effective against most pathogenic microorganisms: Mycoplasma spp., E. coli, Salmonella spp., Campylobacter spp., Haemophilus spp., Pasteurella spp., Bordetella spp., Erysipelothrix rhusiopathiae, Klebsiella spp., Proteus paraemic, Proteus spp. Staphylococcus aureus, Streptococcus spp., Clostridium perfringens, Actinobacillus spp. and enterococci. Enrofloxacin has antimicrobial activity by inhibiting the activity of the enzyme DNA gyrase, which is an extremely important catalyst for DNA replication in bacterial cells. Inhibition of DNA gyrase activity leads to functional disorders, blocking biosynthesis in the cell and death of the pathogen. Enrofloxacin is characterized by bactericidal activity, especially against microorganisms resistant to beta-lactam antibiotics,
Following parenteral administration, enrofloxacin is rapidly and completely absorbed from the injection site. Enrofloxacin is rapidly distributed to body tissues, and after 1-2 hours its active concentration in tissues and tissue fluids is several times higher than the concentration in serum.
Most enrofloxacin is metabolized in the body by N-dealkylation and conjugation with glucuronic acid.
Enrofloxacin is excreted mainly in the urine as glucuronides and partly in the bile. The half-life is from 2 to 7 hours, depending on the species. The half-life in calves is 1.2 hours in dogs.
Application
Enroxil 5% solution for injection is prescribed to farm animals and dogs for infections of the respiratory system, gastrointestinal tract, genitourinary system, colibacillosis, septicemia, salmonellosis, atrophic rhinitis, streptococcus, bacterial and enzootic pneumonia, enzootic pneumonia, pneumonia and enzootic pneumonia. pathogens that are sensitive to enrofloxacin.
Dosage
Cattle, sheep, goats – intravenously or subcutaneously at a dose of 1 ml of the drug per 20 kg of body weight (2.5 mg of enrofloxacin per 1 kg of body weight) once a day. For the treatment of frequent respiratory infections and salmonellosis, the dose is doubled, ie 5 mg of enrofloxacin per 1 kg of body weight. The course of treatment is – 3 days, with salmonellosis – 5 days.
Pigs – intramuscularly at a dose of 1 ml of the drug per 20 kg of body weight (2.5 mg of enrofloxacin per 1 kg of body weight) once a day. For the treatment of frequent respiratory infections and salmonellosis, the dose is doubled, ie 5 mg of enrofloxacin per 1 kg of body weight. The course of treatment is – 3 days, with salmonellosis – 5 days.
Dogs – subcutaneously at a dose of 1 ml per 10 kg of body weight once a day for 5 – 10 days.
Contraindication
Hypersensitivity to enrofloxacin.
Do not use in dogs in the first 12 months of life, as well as during growth, pregnant bitches and lactating bitches.
Do not treat animals with signs of central nervous system disease and impaired renal function. Do not use in animals with insufficient development of cartilage and bone tissue.
Do not use simultaneously with tetracycline drugs, macrolides, chloramphenicol, theophylline.
Do not use for prophylactic purposes, as well as in the detection of pathogens resistant to fluoroquinolones.
Reservation
Quinolone drugs provoke cartilage damage to joints and other forms of arthropathy in fast-growing young animals. Quinolones should be used with caution in animals with or suspected of having CNS disorders.
If the dose exceeds 10 ml for cattle, 5 ml for sheep and goats and 2.5 ml for lambs, goats and pigs, it should be divided and administered in different sections.
Slaughter of animals for meat is allowed 10 days after the last application of the drug. Milk consumption is allowed 7 days (cows) and 5 days (goats) after the last application of the drug, respectively. Meat and milk obtained before this date are disposed of or fed to unproductive animals, depending on the opinion of the veterinarian.
Release form
Bottles made of brown glass, closed with rubber stoppers for aluminum run-in 50 and 100 ml.
Storage
Dry, dark, inaccessible to children at a temperature of 5 ° C to 25 ° C.
Shelf life – 5 years.
After the first selection, the drug must be used within 28 days if stored in the original package at a temperature of 5 ° C to 25 ° C
For use in veterinary medicine!
