Intermectin 1% ( Ivermectin) injection

Description:

Clear solution for injection.

Storage:

1 ml of the drug contains the active substance:

ivermectin 10 mg

fillers (propylene glycol, glycerol formal, water for injections) up to 1 ml.

Pharmacological properties:

ATCvetQP54A, anti-nematode, insecticidal, acaricidal veterinary drugs, (QP54AA01, ivermectin).

The active substance of the drug is ivermectin, which belongs to avermectins. Ivermectin enhances the formation of gamma-aminobutyric acid (GABA) in presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks postsynaptic excitation of an adjacent neuron in nematodes or muscle fibers in arthropods. By stimulating the formation of GABA, ivermectin causes paralysis and death of parasites.

Ivermectin is active against adult gastrointestinal and pulmonary nematodes, their larvae, scabies mites, lice. The drug is effective against gastrointestinal nematodes (adults and larvae of the fourth stage), pulmonary nematodes, ocular nematodes (adults), gnats (parasitic stage), lice, scabies mites: in cattle – Ostertagia ostertagi, Ostertagia lystrongi, Haem axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Bunostomum phlebotomum, Oesophagostomum radiatum, Strongyloides papillosus (adults), Nematodirus helvetianus (adults), Nematodirus spathiger (adults). (adults), Dictyocaulus viviparous (adults and larvae of the fourth stage), Thelazia spp. (adults), Hypoderma bovis, Hypoderma lineatum, Linognathus vituli, Haematopinus eurysternus,

in calves – Ostertagia ostertagi, Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Bunostomum phlebotomum, Oesophagostomum radiatum, Nemlosustiathus papillomatro, , Trichuris spp. (adults), Dictyocaulusviviparous (adults and larvae of the fourth stage), Thelazia spp. (adults), Hypoderma bovis, Hypoderma lineatum. Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus, Psoroptes bovis, Sarcoptesscabieivar bovis; in goats – Ostertagia ostertagi, Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Bunostomum phlebotomum, Oesophagostomum radiatum, Strongyloides papillosus (adults), Nematodirus helvetianus (adults), Nematodirus spathiger (adults), Trichuris spp. (adults), Dictyocaulus filaria (adults and larvae of the fourth stage), Thelazia spp. (adults), Hypoderma bovis, Hypoderma lineatum, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus, Psoroptesbovis, Sarcoptesscabiei;

in sheep – Ostertagia ostertagi, Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Bunostomum phlebotomum, Oesophagostomum radiatum, Nemlosustius papilum, Strongyloathispilus , Trichuris spp. (adults); Dictyocaulus filaria (adults and larvae of the fourth stage); Thelazia spp. (adults); Hypoderma bovis, Hypoderma lineatum, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus, Psoroptes bovis, Sarcoptes scabiei, Oestrus ovis, Melophagus ovenus;

у свиней – Ascaris suum, Hyostrongylus rubidus, Oesophagostomum radiatum, Strongyloides ransomi, Trichuris spp., Metastrongylus spp., Haematopinus suis, Psoroptes suis, Sarcoptes suis.

When administered subcutaneously, ivermectin has a high bioavailability. The drug is slowly absorbed, well distributed throughout the body, but does not penetrate into the cerebrospinal fluid, which reduces its toxicity. High concentrations of ivermectin have been found in the skin, ears and earwax, eyes, indicating that the drug should be effective in the treatment of ectoparasites.

The drug is metabolized in the liver by oxidation and primarily excreted in the feces, less than 5% of the drug is excreted in the urine (half-life for cattle is 2-3 days, for pigs 0.5 days, for sheep 2-7 days).

Application:

Prevention and treatment of cattle, calves, goats, sheep, pigs with invasive diseases caused by:

Ostertagia ostertagi, Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Bunostomum phlebotomum, Oesophagostomum radiatum, Trngyloides papillostius (Strongyloides papillostius) . (adults), Dictyocaulus viviparous (adults and larvae of the fourth stage), Thelazia spp. (adults), Hypoderma bovis, Hypoderma lineatum, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus, Psoroptes bovis, Sarcoptes scabiei var bovis, Oestrusovis, Melophagus ovenus, Ascarissuum, Hyostrongylus rapidhostomom, Ostrostrumus, , Haematopinus suis, Psoroptessuis, Sarcoptessuis.

Dosage:

The drug is administered subcutaneously in the following doses:

Cattle – 1 ml per 50 kg of body weight,

Calves – 1 ml per 50 kg of body weight,

Goats – 1 ml per 50 kg of body weight,

Sheep – 1 ml per 50 kg of body weight,

Pigs – 1 ml per 33 kg of body weight.

Do not enter more than 10 ml of the drug in one place.

Contraindication:

Do not use intravenously or intramuscularly.

Do not use in case of hypersensitivity to the active substance or to any of the excipients.

Reservation:

Slaughter for meat of cattle (including calves), goats, sheep – in 28 days, pigs – in 21 days, after the last use of drug.

The meat obtained before this deadline is disposed of or fed to unproductive animals, depending on the opinion of the veterinarian.

Release form:

Vials made of clear glass are closed with a rubber stopper for aluminum running in 50 and 100 ml.

Storage:

Dark, inaccessible to children place at a temperature from + 15 ° C to + 25 ° C.

Shelf life:  2 years.

After the first selection from the vial, the drug should be used within 14 days, under conditions of storage in a dark place at a temperature of + 2 ° C to + 8 ° C.