1 ml of the drug contains:

levamisole hydrochloride – 80 mg

Description

The liquid is colorless, transparent, without mechanical inclusions, with a faint specific odor.

Pharmacological properties

Levamisole hydrochloride is a synthetic compound from the group of imidazothiales. Inhibits the enzyme of basic fumarate reductase metabolism and ATP formation, paralyzes nerve nodes, causes paralysis and death of nematodes in the first 12-24 hours after administration.

Quickly absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is observed in 1,5-2 hours. Biologically transformed in the liver with the formation of inactive metabolites. The half-life is 3-4 hours, metabolites – about 16 hours. Excreted mainly by the kidneys (more than 95%) in the form of inactive metabolites and gastrointestinal tract (approximately 5%) and less than 0.2% unchanged.

The drug has a complex effect on the immune system, especially in immunosuppressive conditions: increases the production of antibodies to various antigens, activates T-lymphocytes and stimulates their proliferation, increases the function of monocytes, macrophages and neutrophils (chemotaxis, phagocytosis, adhesion).

Indication

Treatment of animals and poultry in diseases caused by:

• cattle, sheep, goats – nematodes of the gastrointestinal tract and lungs Trichostrongylus columbriformis, T. axei, Ostertagia circumcincta, Haemonchus contortus, Nematodirus spathiger, Oesophagostomum venulosum, O. solumbianum, O. radiatum, T. bucephaumum globulosa, Strongyloides papillosus, Dictyocaulus filaria, D. viviparus, Muellerius capillaris, Protostrongylus kochi, Neoascaris vitulorum, etc .;
• pigs – nematodes Brassica campestris, Trichuris suis, Oesophagostoraum dentate, Metastrongylus elongated M. pudendotectus, M. Salmi, M. pulmonary M. tschiauricus, Ollulanus tricuspis O. his trongyloides ransomi;
• dogs — Toxocara canis, T. cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum;
• bird (chickens, geese, turkeys, pigeons) – Ascaridia galli, Heterakis gallinarum, Capillaria spp., Trichostrongylus spp.

Method of application and dosage

Doses and methods of administration of the drug for different species of animals are listed in the table.

Reservation

After the last application of the drug, slaughter of animals and poultry for meat is allowed after 7 days. Meat obtained before this date can be used only for feeding carnivores and making meat and bone meal, and milk – to feed non-productive animals. People should not eat milk and eggs.

Atropine is used as an antidote.

Contraindication

Do not prescribe to females in the last third of pregnancy, breeding breeders during the mating season, laying hens and depleted animals.

Do not use together with pyrantel, morantel, organophosphorus drugs, neostigmine.

Storage conditions

In a dry, dark place at a temperature of +1 to +25 ° C.

Expiration date

3 years.