BROVSEPTOL sodium sulfathiazole, sulfaguanidine, trimethoprim, tylosin tartrate

Arthritis; Dysentery; Colibacteriosis; Mycoplasmosis; Edema disease; Pasteurellosis; Pneumonia; Rhinitis; Erysipelas; Salmonellosis; Typhus; Cholera; Enteritis

Composition

1 g of the drug (1 tablet) contains:

sodium sulfathiazole – 80 mg

sulfaguanidine – 70 mg

trimethoprim lactate – 38 mg

tylosin tartrate – 25 mg

Description

Tablets are light yellow, round or oval, flat.

Pharmacological properties

Combined antibacterial drug with a broad spectrum of action.

Sulfathiazole and sulfaguanidine are antimicrobial bacteriostatic agents from the group of sulfanilamides. Sulfathiazole has a short-term effect, sulfaguanidine – a medium-term effect.

Both sulfanilamides are similar in their spectrum of properties and are active against gram-positive microorganisms – Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Actinomyces israelii, gram-negative – E. coli, Shigella spp. Toxoplasma gondii, coccidia Eimeria stiedae.

The mechanisms of antimicrobial action of sulfathiazole and sulfaguanidine are also similar and are due to antagonism with paraaminobenzoic acid (PABX) and competitive inhibition of dihydropteroate synthetase. This leads to disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines, inhibits the growth of Escherichia coli, reduces the synthesis of thiamine, riboflavin, nicotinic acid in the intestine.

Trimethoprim is a chemotherapeutic agent that is chemically derived from diaminopyrimidine. Acts bacteriostatically against gram-positive microorganisms – Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Gram-negative microorganisms – E. coli, Salmonella spp., Klebsiella spp., Proteus sppla., Pastedella s. etc. The mechanism of action is associated with the inhibition of the enzyme dihydrofolate reductase in the synthesis of tetrahydrofolic acid. This leads to folate deficiency, the main cofactor of nucleic acid synthesis. As a result, the production of nucleic acids and bacterial protein is disrupted. Bacterial dihydrofolate reductase is approximately 50,000 to 60,000 times more strongly bound by trimethoprim than the corresponding mammalian enzyme. The effect is manifested at the stage of folate synthesis, which occurs after as sulfonamides begin to act. Concomitant use with sulfonamides enhances the inhibition of tetrahydrofolic acid production.

Tylosin tartrate is an antibiotic from the group of macrolides. Effective against gram-positive microorganisms – Corynebacterium spp., Clostridium spp., Erysipelothrix spp., Diplococcus pneumoniae, Staphylococcus aureus, some gram-negative microorganisms – Pasteurella spp., Vibrio spp., Leptospisla spp., Leptospisla spp. , rickettsiae Rickettsia spp., spirochetes Spirochaetales, mycoplasmas Mycoplasma gallisepticum, M. synoviae, M. meleagridis. Tylosin acts bacteriostatically, inhibiting protein synthesis, due to irreversible connection with the 50S subunit of bacterial ribosomes. Stops the growth and reproduction of microbial cells, inhibits RNA synthesis in the ribosomes of bacterial cells at any stage of the ribosomal cycle.

Sulfathiazole is well absorbed from the gastrointestinal tract and acts systemically. Sulfaguanidine is almost not absorbed, due to which there is a high concentration in the intestine and the maximum effect is achieved in the treatment of gastrointestinal diseases. Sulfanilamides penetrate well into tissues and body fluids, including pleural effusion, peritoneal and synovial fluid, middle ear exudate, ventricular moisture, urogenital tract tissue, pass through the placenta and into milk. Metabolized in the liver, mainly by acetylation, with the formation of microbiologically inactive but toxic metabolites. Excreted by the kidneys about half unchanged (with an alkaline reaction of urine excretion increases), a small amount is excreted in the bile. In renal failure, the accumulation of sulfonamides and their metabolites in the body is possible,

When taken orally, tylosin is rapidly absorbed from the gastrointestinal tract and within an hour there is a sufficient bacteriostatic level in the blood and tissues. Therapeutic concentrations of the drug are stored in serum for 6-8 hours. It is metabolized mainly in the liver and excreted unchanged mainly in the urine and partly in the feces, in laying birds – with eggs, in lactating animals – with milk.

Absorption of trimethoprim from the gastrointestinal tract occurs rapidly and almost completely (90-100%), binding to plasma proteins – up to 70%. High concentrations of trimethoprim are observed in the secretion of bronchial glands, prostate and bile. It crosses the placental barrier and enters the milk. The half-life in plasma is 8-10 hours. The kidneys excrete 50-60% within 24 hours mainly by glomerular filtration and tubular secretion, with 80-90% – unchanged, the rest – in the form of inactive metabolites, a small amount (4%) – with bile.

Indication

Treatment of animals and poultry for diseases of the gastrointestinal tract, respiratory system and genitourinary system caused by microorganisms sensitive to the active substances of the drug:

• calves under 3 months – gastroenteritis, salmonellosis, pasteurellosis, vibriosis;
• pigs – enzootic pneumonia, arthritis, dysentery, edema, erysipelas, salmonellosis, pasteurellosis;
• lambs under 3 months of age – septicemia, eimeriosis;
• rabbits – gastroenteritis, colibacillosis, pasteurellosis, coccidiosis, pneumonia;
• poultry (broiler chickens, turkeys, ducks, geese) – typhus, cholera, salmonellosis, mycoplasmosis, rhinitis.

Contraindication

Do not use in animals with hypersensitivity to the active substances of the drug, impaired liver and kidney function, lactating and pregnant females.

Do not use in ruminants with functionally developed pancreas, laying hens, whose eggs are eaten by humans.

Do not use simultaneously with penicillins, cephalosporins, lincomycin, paraaminobenzoic acid and its compounds.

Method of application and dosage

The tablets are administered orally with feed, pre-grinding. The daily dose for all species of animals is 1.5-2 g or 1.5-2 tablets (111-148 mg of sulfathiazole, 105-140 mg of sulfaguanidine, 44-58 mg of trimethoprim, 32-43 mg of tylosin) per 10 kg of body weight body, it is given in two doses, the course – 4-5 days (until the complete disappearance of symptoms). Treatment can be extended for 1-2 days. At the first application, depending on the condition of the animal, the dose can be increased by 30-100%.

*Kilograms to a Pounds conversion table

Reservation

With long-term use of the drug may develop allergic reactions (skin rash, urticaria, pruritus), hepatitis, crystalluria, blood pathologies (leukopenia, agranulocytosis, thrombocytopenia).

In ruminants, the drug can inhibit the growth and reproduction of the symbiotic microflora of the rumen, which is involved in the synthesis of vitamins. Therefore, it is advisable to use B vitamins at the same time, not to limit the animals in the water and to feed foods rich in proteins and vitamins.

Some drugs, such as salicylates and phenylbutazone, may interfere with the binding of sulfonamides to plasma proteins and thereby increase the toxicity of sulfonamides. Paraaminobenzoic acid derivatives, such as novocaine, tetracaine and procainamide hydrochloride, reduce the antimicrobial activity of sulfonamides.

Do not use with antibiotics that are antagonists of the components of the drug (chloramphenicol, monomycin, ceporin, ristomycin, kanamycin).

After the last application of the drug slaughter of animals and poultry for meat is allowed in 8 days. Meat obtained before this date is disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.

Storage conditions

In a dry, dark place, out of reach of children at a temperature of +4 to +25 ° C.

Expiration date

2 years.