Dermatological liquid for CATS and DOGS
(triamcinolone, methionine, succinic acid, vitamin B2, vitamin B3, vitamin B6)
1 ml of the drug contains:
triamcinolone – 1 mg
methionine – 50 mg
succinic acid – 2 mg
vitamin B 2 (riboflavin) – 5 mg
vitamin B 3 (PP, nicotinamide) – 10 mg
vitamin B 6 (pyridoxine) – 3 mg
Light yellow or dark yellow suspension.
Triamcinolone is a synthetic fluorine-containing glucocorticoid with pronounced anti-inflammatory, anti-allergic, desensitizing, and antitoxic effects.
Anti-inflammatory properties are due to the stabilization of cell membranes, including labrocytes and organelles (lysosomes), inhibition of phospholipase A2 activity, cessation of the release of arachidonic acid from phospholipids of cell membranes, and reducing the level of products of its metabolism. Inhibits hyaluronidase, inhibits the division of labrocytes and reduces their degranulation, inhibits the synthesis of platelet-activating factor and connective tissue proliferation. By reducing the number of T- and B-lymphocytes, disrupting their interaction, stopping the migration of B-lymphocytes provides the immunosuppressive and antiallergic effect. Reduces the content of immunoglobulins in the serum, inhibits the cooperation of phagocytes and lymphocytes. Antishock and antitoxic action is based on reducing the permeability of vascular endothelium, membrane-protective properties, and activation of liver enzymes,
The bioavailability of triamcinolone after oral administration is 20-30%. The action begins in 1-2 hours and lasts for 6-8 hours. The half-life from blood serum is 2-5 hours, from tissues – 18-36 hours. Triamcinolone is 40% bound to serum proteins, mainly globulins. It is metabolized in the liver, a small amount – in the kidneys. Excreted mainly in the urine as inactive metabolites.
Methionine – an essential amino acid, is a source of sulfhydryl and methyl groups, has a lipotropic effect (prevents the accumulation of fat in the liver in choline deficiency, which is involved in the synthesis of phospholipids). Neutralizes toxic metabolic products by methylation and transsulfuration.
Succinic acid accelerates the regeneration of damaged skin cells, stimulates and normalizes energy and plastic metabolism, has antitoxic effects, enhances biochemical and physiological regenerative processes in the epidermis and eliminates metabolic acidosis in tissues.
B vitamins play an important role in metabolism, are involved in cellular redox reactions of amino acids. These vitamins significantly improve the condition of the skin, especially in seborrheic dermatitis and pellagra. They are easily absorbed in the small intestine and excreted in the urine as various metabolites.
Method of application and dosage
Before use, the vial is thoroughly shaken and administered orally once a day, during the morning feeding with a small amount of food or injected directly into the root of the tongue with a syringe-dispenser. Doses of the drug for the treatment of animals in the first 4 days are given in the table.
|Animal species||Bodyweight (kg)||Daily dose (per animal, ml)|
|30-40 and more||2|
|3 and more||0.5|
For treatment in the next 8 days the dose is reduced twice. After consultation with a veterinarian, the duration of treatment may be extended.
When using the drug in the recommended doses of side effects and complications are not observed. Occasionally, some animals may vomit, depression, excessive salivation, gastrointestinal disorders. In these cases, the drug should be discontinued.
Treatment of dogs and cats for inflammatory, allergic, autoimmune, and other diseases of the skin and joints.
Do not prescribe to animals sensitive to the active substances of the drug, for systemic fungal infections, acute infectious diseases, diabetes, pregnant and lactating animals, kittens under 2 months of age, puppies under 3 months of age.
Do not use during vaccination periods, especially live antiviral vaccines, and concomitantly with other corticosteroids.
In a dry dark place, out of reach of children, at a temperature of +4 to +25 ° C.
After opening the vial, use the drug for 28 days.