BROFOM NEW Complex antimicrobial drug with a broad spectrum of action

Arthritis, dysentery, colibacillosis, mycoplasmosis, pasteurellosis, pneumonia, rhinitis, salmonellosis, enteritis

DESCRIPTION
Storage
1 g of the drug contains:
colistin sulfate – 500,000 IU
oxytetracycline hydrochloride – 35 mg
trimethoprim – 27 mg

Description
Light yellow powder, soluble in water.
Pharmacological properties
A complex antimicrobial drug with a broad spectrum of action.
Oxytetracycline is a bacteriostatic antibiotic, when interacting with ribosomes oxytetracycline disrupts protein synthesis and reduces the permeability of the cytoplasmic membrane of microorganisms, acts against gram-positive and gram-negative microorganisms – Streptococcus spp., Clostridium spp., Coryl spp., Coryl spp. , Pasteurella spp., Klebsiella spp., Erysipelothrix spp., Fusobacterium spp., Salmonella spp., Protozoa protozoa, Mycoplasma spp. Mycoplasmas, Rickettsia spp. Rickettsiae, Chlamydia chlamydia. Forms metabolites in small quantities, excreted in urine, bile and milk.
Colistin – an antibiotic from the group of polymyxins, acts on gram-negative microorganisms E. coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp. Colistin binds phospholipid A to cell membranes and neutralizes the action of bacterial endotoxin, which leads to the destruction of the membrane structure. The permeability of the cell membrane changes immediately after contact with the drug. It is absorbed from the gastrointestinal tract in small quantities, so high concentrations of the drug are observed in its various departments. Excreted by the kidneys as active metabolites.

Trimethoprim acts against gram-positive bacteria Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Gram-negative bacteria E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp., Bordelltel spp. etc. Blocks protein synthesis in bacteria, inhibits bacterial reductase, which converts dehydrofolic acid to tetrahydrofolic acid, which is required for the synthesis of purines and nucleic acids. 70% bound to plasma proteins, high concentrations of trimethoprim are observed in the secretion of bronchial glands, prostate and bile. The half-life in blood plasma is 8-10 hours, after 72 hours it is excreted in the urine by 66.8%.

APPLICATION
Method of application and dosage
The drug is administered orally in the following doses:

• pigs, poultry (group treatment) – 1 kg per 1000 liters of drinking water or 1.5-2 kg of the drug per 1 ton of feed, the course – 3-5 days;
• rabbits, poultry – 1-1.5 g per 1 liter of drinking water, the course – 3-5 days;
• calves, lambs under 6 weeks of age, piglets (individual treatment) – 0.5 g per 10 kg of body weight, 2 times a day, the course – 5-7 days.

Reservation
After the last application of the drug, slaughter of calves, lambs, pigs, rabbits for meat is allowed in 10 days, poultry – in 7 days. Meat obtained before this date is disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.

Indication
Treatment of animals with diseases caused by gram-positive, gram-negative and other microorganisms:
• pigs – dysentery, colibacillosis, pasteurellosis, salmonellosis, diseases of the gastrointestinal tract and respiratory organs;
• calves, lambs under 6 weeks of age, rabbits – enteritis, respiratory diseases;
• poultry (broiler chickens, turkeys, pheasants, geese, ducks) – mycoplasmosis, colibacillosis, pasteurellosis, respiratory diseases.
Contraindication
Do not prescribe to animals with hypersensitivity to the active substances of the drug, impaired liver and kidney function, ruminants with functionally developed pancreas. Do not use in laying hens, the eggs of which are eaten by humans.
The drug is incompatible with hydrocortisone, heparin, dicylene, cephalosporins, amphotericins and aminoglycosides.
Storage conditions
In a dry, dark place, out of reach of children at a temperature of +8 to +25 ° C.
Expiration date
3 years.