ESTROFA (cloprostenol sodium salt) Solution, 20 ml (Cystorelin, Synchsure, EstroPlan analog)
(injection)
Description
Injection.
Compound
1 ml of the drug contains:
cloprostenol sodium salt – 0.25 mg.
Excipients: sodium hydroxide, chlorcresol, citric acid, water for injection.
Pharmacological properties
ATCvet QG02AD90
Cloprostenol is a synthetic functional analog of prostaglandin F2-alpha, which in the luteal phase of the estrous cycle causes lysis of the corpus luteum, promotes the growth and development of follicles and creates the prerequisites for the onset of estrus and ovulation.
Application
Cattle:
– to accelerate the involution of the uterus;
– during the detention of the placenta;
– with “hidden” hunting;
– with violations of the cyclicity of the sexual cycle and anovulatory sexual cycle;
– to accelerate the regression of the persistent corpus luteum and the treatment of the luteal cyst;
– for the treatment of endometritis;
– to interrupt the physiological and pathological course of pregnancy;
– with a false pregnancy.
Mares:Β to stimulate estrus and lysis of the persistent corpus luteum, in case of embryonic miscarriages, in lactational anestrus, in the first half of physiological and pathological pregnancy, in false pregnancy.
Sheep:Β to synchronize estrus and treat dysfunctional conditions of the ovaries.
For sows:Β for stimulation of labor and synchronization of farrowing, prevention of postpartum diseases.
Bitches, cats:Β in the complex therapy of chronic endometritis and for the termination of unwanted pregnancies.
Dosage
The drug is administered intramuscularly
Cattle
To synchronize hunting, 2 ml of the drug (0.50 mg of the active substance) is administered 2 times with an interval of 10 days.Β The first injection of the drug is administered in any phase of the sexual cycle (in cows in the period 40-60 days after growing up).Β On the 11th day after the first injection, the second dose is administered, on the 14th day (72-76 hours after the second dose), artificial insemination is carried out (despite external signs of estrus), followed by repeated artificial insemination (day 15).Β Before each use of the drug to synchronize the sexual cycle, it is necessary to conduct an examination of the genital organs.Β A prerequisite for the treatment of animals with estrophalan is the physiological state of their genitals, in dry cows – their sexual and physiological maturity.
With functional disorders of the ovaries, 2 ml of the drug is administered, artificial insemination is carried out when signs of estrus appear.Β If estrus has not occurred, the drug is administered again at a dose of 2 ml on the 11th day after the first injection, followed by artificial insemination after 72-76 hours, if necessary, repeat artificial insemination.Β For the treatment of follicular cysts, a single dose of 2 ml of the drug is administered, not earlier than on the 10th day after the administration of the chorionic hormone, when a positive ovarian response is established.
In case of postpartum diseases of the uterus (postpartum metritis, subinvolution of the uterus), to remove the βprogesterone blockβ and normalize the estradiol-progesterone ratio, which ensures the effect of myotonic drugs on the uterus, 2 ml of the drug is administered, if necessary, treatment can be supplemented with intrauterine local sanitation, on the 11th day – re-introduction, 14th day – artificial insemination, 15th day – repeated artificial insemination.
To interrupt the physiological course of pregnancy, 2 ml of the drug is administered between 7 and 150 days of pregnancy, and up to 100 days the drug is most effective (further care depending on the clinical condition).
To terminate a pathological pregnancy, 2 ml of the drug is administered at any stage of pregnancy, after which the mummified fetus is expelled from the uterus into the vagina and its further removal.
Sows
A single dose is 0.5-0.7 ml of the drug (0.175 mg of the active substance), administered from the 111th day of pregnancy.Β Most induced farrowing occurs up to 40 hours after administration, culminating between 24-35 hours.
SheepΒ – 0.5-0.7 ml.
To synchronize estrus during the period of the breeding campaign, females that did not come into estrus after the first injection are given a second injection at the same dose.
Infertile ewes in a state of anaphrodisia with ovarian dysfunction, the drug is administered simultaneously with FFA gonadotropin at a dose of 500 IU.Β Sheep that did not come into heat, the drug in the same dose after 10-11 days is administered again.Β Hunting in sheep is detected by probe rams twice – in the morning and in the evening, with their subsequent insemination.
Mares
A single dose is 1 ml of the drug (0.25 mg of the active substance).Β For mares with an inferior sexual cycle, the drug is administered in the period from 5 to 13 days after estrus.Β The most optimal time for insemination is 4-6 days after the administration of the drug.
BitchesΒ – 0.2-0.3 ml.
CatsΒ – 0.1 ml, to induce abortion, 3-5 injections are needed with an interval of 12 hours.
*Kilograms to a Pounds conversion table
Kilograms (kg) | Pounds (lb) | Pounds+Ounces (lb+oz) |
0.1 kg | 0.220 lb | 0 lb 3.527 oz |
1 kg | 2.205 lb | 2 lb 3.274 oz |
5 kg | 11.023 lb | 11 lb 0.370 oz |
10 kg | 22.046 lb | 22 lb 0.740 oz |
Contraindications
Do not use in females in the first third of pregnancy (except in cases of purposeful termination of pregnancy).
Warning
Do not administer intravenously.
Release form
Glass ampoules of 1, 2, 5 ml and bottles of 10, 20, 50, 100, 200 ml.
Storage
Dry, dark place at temperatures from 5ΛC to 25Β°C.
Shelf life – 2 years.