Dehinel Plus XL tablets for dogs (praziquantel, pyrantel embonate, febantel)

Description

Oval biconvex, slightly greenish-yellow in color with beveled edges and a notch on one side.

Composition

1 tablet (2310 mg) contains active ingredients:

• praziquantel – 175 mg
• pyrantela embonate – 504 mg,
• febantel – 525 mg

Excipients: lactose, corn starch, K30, sodium lauryl sulfate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate.

Pharmacological properties

ATC vet QP52, veterinary anthelmintic drugs

Dehinel Plus XL tablets for dogs is a combined action anthelmintic drug-containing praziquantel, pyrantel embonate and febantel.

Pirantela embonate and febantel are effective against nematodes (ascaridate, hookworm, whipworm), including Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis. Praziquantel is effective against the preimaginal and imaginal stages of tapeworm development, in particular Taenia spp., Dipylidium caninum, Echinococcus granulosus, Echinococcus multilocularis and Mesocestoides spp.

Pyrantel acts as a cholinergic antagonist, the mechanism of action of which is to stimulate the nicotinic cholinergic receptors of the parasite, causing spastic paralysis and thus allows the parasite to be removed from the digestive tract by peristalsis.

Febantel derivatives – fenbendazole and oxfendazole – have an anthelmintic effect by inhibiting tubulin polymerization. Thus, the formation of microtubules is prevented, leads to disruption of structures vital for the normal functioning of helminths, in particular, the absorption of glucose is disrupted, which leads to depletion of ATP in the cells. The parasite dies as a result of depletion of energy reserves, which occurs after 2 – 3 days.

Praziquantel is rapidly absorbed and spread throughout the body of the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite’s membrane, leading to spasm and paralysis. There is an almost instantaneous tonic muscle spasm of the parasite and rapid vacuolization of the syncytial membrane. This rapid cramp is caused by changes in bivalent cationic fluxes, in particular calcium.

Application

Deworming dogs, including puppies, with nematodes and cestodes:

• Ascaridata – Toxocara canis, Toxascaris leonina (mature and larval forms)
• Hookworms – Ancylostoma caninum, Uncinaria stenocephala (sexually mature forms)
• Whipworm – Trichuris vulpis (sexually mature forms)
• Tapeworms – Dipylidium caninum, Taenia pisiformis, T. hydatigenia, T. multiceps, Echinococcus granulosus, E. multilocularis, Mesocestoides lineatus.

Dosage

Orally once with food or by force.

The dose of active ingredients of the drug is 15 mg of febantel, 14.4 mg of pyrantel and 5 mg of praziquantel per 1 kg of body weight.

Dose: 1 tablet Dehinel Plus XL tablets for dogs per 35 kg bodyweight of the animal. Combined preparations of Dehinel Plus XL tablets for dogs with the preparation Dehinel Plus tablets with meat flavor for dogs (1 tablet / 10 kg of body weight) are used for animals weighing more than 35 kg.

Deworming of females for toxocariasis and toxascarosis is carried out according to the following scheme: the drug is given to females 2 weeks after giving birth and every two weeks until the end of the period of feeding the puppies.

In case of severe damage to animals by nematodes, it is recommended to use the drug twice with an interval of 14 days.

It is recommended to deworm animals every 3 months.

*Kilograms to Pounds conversion table

Contraindications

Do not use on sick and weakened animals!

Do not use in pregnant females in the first two-thirds of pregnancy. If it is necessary to carry out deworming of pregnant females, it is necessary to consult a veterinary doctor.

Warning

Adhere to the recommended dosage.

When working with the drug, observe the basic rules of hygiene and safety adopted when working with veterinary drugs.

Release form

6 tablets in a blister, 2 blisters in a carton box.

Storage

Dry, dark, inaccessible to children, place at a temperature of 5 to 25 ° C. Store in original packaging.

Shelf life is 3 years.

For use in veterinary medicine!