Powder Bramulin-plus for pigs Tiamulin+oxytetracycline

Arthritis, dysentery, colibacillosis, mycoplasmosis, pasteurellosis, pneumonia, rhinitis, salmonellosis, enteritis

DESCRIPTION

Storage
1 g of the drug contains:

tiamulin hydrogen fumarate – 33.3 mg
oxytetracycline hydrochloride – 100 mg

Description
The light yellow powder, with a specific odor, dissolves in water.

Pharmacological properties
The combination of thiamulin and oxytetracycline has a wide range of bacteriostatic action against most species of mycoplasmas Mycoplasma hypopneumoniae, M. hyorhinis, M. synoviae, M. hyosynoviae, Ureaplasma spp. respiratory and digestive infections – Salmonella spp., Bordetella spp., Erysipelothrix spp., Pasterella spp., Pseudomonas spp., E. coli, Campylobacter coli, etc.

Tiamulin hydrogen fumarate acts bacteriostatically, and in very high concentrations – bactericidal. The mechanism of action is the connection with the 50S ribosomal subunit of sensitive bacteria, which leads to disruption of protein synthesis in the bacterial cell. Tiamulin is active against many gram-positive cocci, including most Staphylococcus spp., Streptococcus spp. (but not D. streps), mycoplasmas and spirochetes. The activity of tiamulin against gram-negative microorganisms is low, except for Haemophilus srp. and some strains of E. coli and Klebsiella spp.

Tiamulin is rapidly absorbed from the gastrointestinal tract, its maximum concentration in the serum is observed in 2-4 hours after application. After assimilation, it is intensively distributed in tissues and organs, the highest concentrations are recorded in the liver, and the lowest – in the muscles. It is completely metabolized and rapidly excreted in the urine (20-24% of the applied dose) and bile. It remains unchanged in the liver and kidneys only for 1 day after stopping treatment.

Oxytetracycline belongs to the group of tetracyclines and acts bacteriostatically. Inhibits protein synthesis by binding to the 30S ribosomal subunit of microorganisms and prevents them from binding to ribosomal aminoacyltransport RNA. Tetracycline also binds back to 50S ribosomes and alters the permeability of the cytoplasmic membrane of sensitive microorganisms. Active against most mycoplasmas, spirochetes (including those that cause borreliosis), chlamydia and rickettsiae, some strains of gram-positive bacteria: Staphylococcus spp., Streptococcus spp., Actinomyces spr., Bacillus anthracis, Clostridium norcyangenes and C. spp. Active in vitro and in vivo against gram-negative bacteria Bordetella spr., Brucella spr., Bartonella spr., Haemophilus spr., Pasturella multocida, Shigella spr., Yersinia restis.

After application oxytetracycline is quickly and completely soaked up. After 30 minutes, its concentration in the serum is almost 60% of therapeutic, the maximum concentration is reached after 2 hours. Oxytetracycline is evenly distributed in tissues, except for nerve and fat, 20-25% binds to plasma proteins. It is almost not metabolized in the body – about 60% is excreted in the urine unchanged, the rest – with bile.

Method of application and dosage
The drug is used with drinking water or feed mainly by the group method. During the preparation of the therapeutic-feed mixture, the drug should be thoroughly mixed with compound feed. Such LKS can be stored and used for 3 months.

The therapeutic dose of the drug is 30 g per 10 kg of feed. In severe pneumonia or gastrointestinal infections, the dose can be increased to 40-45 g. When used with drinking water, the daily therapeutic dose is 1.5-2 g per 1 liter of water, the course is 5 days.

Before preparing the treatment solution, prepare a concentrate: the calculated dose of the drug is placed in a plastic or enamel dish, add 10 parts of water at a temperature of + 40-45 ° C and mix. The resulting mixture is added to the daily norm of water.

Reservation
After the last application of the drug, slaughter of animals for meat is allowed in 10 days. Meat obtained before this date is disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.

Indication
Treatment of pigs with dysentery, colibacillosis, pasteurellosis, salmonellosis, atrophic rhinitis, enzootic pneumonia, pleuropneumonia, proliferative enteropathy (ileitis), arthritis of bacterial etiology, infections that accompany viral transmission.