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hormone of the hypothalamus, which consists of pentapeptydnoho cycle and side chain residues of three amino acids that accumulate in the posterior pituitary. It increases the permeability of sodium myofibrils uterus, stimulating its contraction. Threshold oxytocin induced contractions of the uterus decreases during pregnancy, high estrogen or if the animal has already begun delivery.
Oxytocin is decomposed in the gastrointestinal tract, so it should be administered parenterally. After intramuscular administration of the drug effect observed after 3-5 minutes.hormone of the hypothalamus, which consists of pentapeptydnoho cycle and side chain residues of three amino acids that accumulate in the posterior pituitary. It increases the permeability of sodium myofibrils uterus, stimulating its contraction. Threshold oxytocin induced contractions of the uterus decreases during pregnancy, high estrogen or if the animal has already begun delivery.
Oxytocin is decomposed in the gastrointestinal tract, so it should be administered parenterally. After intramuscular administration of the drug effect observed after 3-5 minutes.Oxytocin has the ability to selectively increase the tone and contractile activity of the smooth muscles of the uterus, especially towards the end of pregnancy, during labor and directly during delivery. It acts on specific receptors in the myometrium and increases the intracellular Ca2 + content. Stimulates rhythmic contractions of the uterus – intensifies and increases their frequency. Acts on the myoepithelial elements of the mammary gland, causes a contraction of the smooth muscles of the walls of the alveoli and stimulates the flow of milk into the large ducts or sinuses, facilitates its release. It has pressor properties and can cause an antidiuretic effect when used in large doses. T1 / 2 from plasma – about 1-6 minutes (decreases in late pregnancy and during lactation). After intravenous administration of oxytocin, the reaction of the uterus manifests itself almost immediately, and then gradually decreases within 1 hour, after intramuscular injection – after 3-7 minutes and lasts 30 minutes – 3 hours. It is well and quickly absorbed into the systemic circulation through the nasal mucosa … T1 / 2 – less than 10 minutes, excreted mainly by the kidneys (only a small amount in unchanged form) and the liver. It is actively secreted by the lactating mammary glands. The effect is very individual and depends on the density of oxytocin receptors in the myometrium.
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