Neomycin sulfate is a broad-spectrum antibiotic. It is active against many gram-positive and gram-negative microorganisms, including those resistant to other antibiotics (penicillin, streptomycin, chloramphenicol, tetracycline). It does not affect pathogenic fungi, viruses and anaerobic flora. Microorganism resistance to neomycin develops slowly to a small extent. It is not inactivated by inflammatory exudates, enzymes, gastric juice. With oral administration of neomycin, sulfate is almost not absorbed and has a local effect on the intestinal microflora. It is excreted from the body mainly with feces and urine.