Prodex eye and  ear drops for dogs and cats (Ciprodex analog)

Ciprofloxacin+Dexamethasone drops

Treatment of dogs, cats, small, exotic and decorative animals with acute and chronic inflammation of the eyes and ears that are the result of bacterial, chemical or traumatic effects – conjunctivitis, blepharitis, keratitis, keratoconjunctivitis, iritis, iridocyclitis, ulcers and erosion of the cornea, eye diseases after injuries or ingress of foreign bodies or aggressive compounds in the after and preoperative periods, as well as otitis media, otorrhea, in particular, caused by the extraneous intervention.

Before using Prodex drops, you should carefully read the instructions and consult a veterinarian.

Suspension for external use (eye&ear drops) 1 ml contains:

• ciprofloxacin 4.5 mg
• dexamethasone 1 mg

Pharmacological properties:

Combined chemotherapeutic agent combining a broad-spectrum antibiotic from the group of fluoroquinolones (ciprofloxacin) and GCS (dexamethasone), with antibacterial, anti-inflammatory, anti-allergic and desensitizing properties.

Ciprofloxacin acts bactericidal by inhibiting DNA gyrase and inhibiting the synthesis of bacterial DNA. Active against gram-negative microorganisms during dormancy and division – Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Vibrio spp., Campylobacter spp., Hafnia spp., Providencia stuartii, Haemophilus spp., Pasteurella multocida, Pseudomonas spp., Gardnerella spp., Neisseria spp., Moraxella catarrhalis, Acinetobacter spp., Brucella spp., gram-positive microorganisms during the division – Staphylococcus spp., Streptococcus pyogenes, Streptococcus agalactiae, Соrynebacterium diphtheriae , Listeria monocytogenes and other pathogens – Chlamydia spp., Mycoplasma spp., Mycobacterium spp-

It is well absorbed, after 60 minutes its concentration in the tear fluid is 4.98 μg / ml, and in the fluid of the anterior chamber of the eye – 2.59 μg / ml. The half-life of the anterior chamber of the eye is 2 hours. When instilled into the eyes, the concentration of ciprofloxacin in the blood does not exceed 2.5 ng / ml, while instilled into the ears, the maximum concentration in the blood is reached after 15-90 minutes and is approximately 0.1% of the concentration of ciprofloxacin, administered orally at a dose of 250 mg.

Dexamethasone is a synthetic fluorinated GCS with anti-inflammatory, anti-allergic, and antiproliferative effects. Reduces capillary permeability and proliferation, local exudation, cell infiltration, phagocytic activity, collagen deposition, and fibroblast activity, inhibits the formation of scar tissue and inflammation symptoms. The anti-inflammatory effect after instillation lasts 4-8 hours. When applied topically, systemic absorption is low. After instillation into the eyes, dexamethasone penetrates well into the corneal epithelium, conjunctival cells, and into the fluid of the anterior chamber of the eye, its maximum concentration of 30 ng/ml is reached after 2 hours, the half-life is 3 hours. When used in the ears, the maximum concentration in the blood is reached after 15-90 minutes and is approximately 14% of the concentration of dexamethasone administered orally at a dose of 5 mg.

Dosage and administration:

The drug is instilled in the conjunctival sac 1-2 drops 2-4 times a day (in difficult cases, 1-2 drops are instilled for 1-2 days every 2-3 hours), or the ear canal is 1-4 drops (depending on weight animal) 2-3 times a day.

In the presence of significant purulent or mucopurulent discharge, preliminary hygienic treatment of the eyes or ears is carried out: 3-4 drops are instilled and the discharge is removed with a sterile gauze swab, after which 1-2 drops of the drug are instilled. The course of treatment until complete recovery is 5-10 days.

Precautions:

When instilled into the eyes, local irritation, itching, and lacrimation, which quickly pass, are sometimes possible, occasionally allergic reactions, and with prolonged use, the development of secondary glaucoma, steroid cataract. Gently apply to animals for up to 7 days.

Contraindications:

Do not prescribe to animals with hypersensitivity to the active substances of the drug.

Packaging:

Polymer bottles with a dropper of 10 ml in an individual cardboard box.

Storage:

In a dry, dark place inaccessible to children, at a temperature of +10 to + 25 ° C.

After opening the bottle, use the drug for 30 days.