Oxytetracycline 200 mg/ml, Sterile Solution Oxyprol (Vetrimycin, Liquamycin analog)

Oxytetracycline antibiotics of the tetracycline group for Cattle, Sheep, Goats, Pigs, Turkeys

Storage

1 ml of the drug contains:

oxytetracycline dihydrate (hydrochloride) – 200 mg

Description

The liquid is light yellow, homogeneous, transparent.

Pharmacological properties

Oxytetracycline – an antibiotic of the tetracycline group, inhibits protein synthesis by binding to the 30S ribosomal subunit of drug-sensitive microorganisms, which prevents the connection of ribosomes with aminoacyltransport-RNA. It is believed that oxytetracycline binds back to the 50S subunits of the ribosome and alters the permeability of the cytoplasmic membrane of susceptible microorganisms.

After administration of the drug, the maximum concentration of oxytetracycline dihydrate in blood plasma is observed in 2-3 hours and persists for 72-96 hours.

Oxytetracycline binds to plasma proteins by more than 80%, is distributed throughout the body, reaching the heart, kidneys, lungs, muscles, pleural fluid, bronchial secretions, sputum, bile, salivary, synovial and ascitic fluid, intercellular space and vitreous, in small quantities – in saliva, eye fluid and milk. The drug penetrates the placental barrier, poorly penetrates the cerebrospinal fluid, but in meningitis, its content in the cerebrospinal fluid can reach therapeutic levels. The elimination period in dogs and cats is 4-6 hours, in cattle – 4.3-9.7 hours, in horses – 10.5 hours, in pigs – 6.7 hours, in sheep – 3.6 hours. It is excreted mainly unchanged in the urine through the kidneys and bile through the gastrointestinal tract.

Indication

Treatment of animals with diseases caused by gram-positive microorganisms Staphylococcus spp., Streptococcus spp., Erysipelothrix spp., Clostridium spp. etc., gram-negative microorganisms Pasteurella spp., E. coli, Salmonella spp., Bordetella bronchiseptica, Haemophilus parasuis, Actinobacillus pleuropneumoniae, etc., protozoa protozoa, Mycoplasma spp. mycoplasma, Chickyla

• cattle – actinomycosis, anaplasmosis, leptospirosis, chlamydia, bronchopneumonia, pneumonia, necrobacteriosis, purulent-necrotic lesions of the extremities, septic condition with inflammation of the joints, skin, udder, uterus, infectious keratoconjunctivitis (help);
• sheep, goats – pasteurellosis, infectious abortion, hoof rot, umbilical sepsis, diseases of the respiratory system, gastrointestinal tract, urogenital tract;
• pigs – atrophic rhinitis, erysipelas, MMA syndrome, leptospirosis, mycoplasmosis, pasteurellosis, chlamydia, dysentery, diseases of the joints, respiratory system, gastrointestinal tract, urogenital tract;
• rabbits – infectious rhinitis, mycoplasmosis, respiratory diseases, gastrointestinal tract, wound infections;
• turkeys – colibacillosis, pullorosis, respiratory mycoplasmosis, ornithosis, gastrointestinal diseases.

Contraindication

Do not use in animals with hypersensitivity to oxytetracycline, hepatic or renal impairment during pregnancy.

Do not use in horses, dogs and cats.

Do not use simultaneously with penicillins, cephalosporins, quinolones, sulfonamides, phenylbutazone.

Method of application and dosage

The drug is administered deep intramuscularly, once.

The dose of the drug for cattle, pigs, sheep, goats is 1 ml per 10 kg of body weight (20 mg of oxytetracycline per 1 kg of body weight).

Doses of the drug for newborn piglets per 1 animal are:

• in the 1st week of life – 0.3 ml;
• in the 2nd week of life – 0.4 ml;
• in the 3rd week of life – 0.5 ml;
• more than 3 weeks – 0.1 ml per 1 kg of body weight.

For rabbits and turkeys, the dose is 0.25 ml per 1 kg of body weight.

Injections larger than the following values ​​are divided into several parts and injected in different places:

• adult cattle – 20 ml;
• pigs – 10 ml;
• calves, sheep, goats – 5 ml.

*Kilograms to a Pounds conversion table

Reservation

If you have signs of allergies in sick animals, you must immediately enter a solution of adrenaline, caffeine, antihistamines or corticosteroids.

After the last application of the drug slaughter of animals and poultry for meat is allowed in 21 days, people can eat milk in 7 days. Meat and milk obtained earlier than this period are disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.

Storage conditions

In a dry, dark place, out of reach of children at a temperature of +5 to +25 ° C.

After opening the vial, store the drug in the refrigerator and use for 20 days.

Expiration date

2 years.