MAXI BROVSEPTOL (sulfadimethoxine + sulfadiazine + trimethoprim)

DESCRIPTION

1 g of the drug contains:

sulfadimethoxine sodium salt – 300 mg

sulfadiazine sodium salt – 300 mg

trimethoprim – 120 mg

Description
The powder is light yellow, homogeneous, with a faint specific odor, soluble in water.

Pharmacological properties
Combined broad-spectrum antibacterial drug against gram-positive and gram-negative bacteria – Staphylococcus spp., Streptococcus spp., Neisseria spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., E. coli, Salmonella spp. , Citrobacter spp., Pasteurella spp., Bordetella spp., Enterobacter spp., Yersinia enterocolitica, Chlamidya spp., Vibrio cholerae, etc., some of the simplest – Pneumocystis carinii, Coccidia, Toxoplasma.

Sulfanilamides and trimethoprim (a derivative of diaminopyrimidine) block enzymes in two successive stages of folic acid biosynthesis in the bacterial cell, which leads to inhibition of bacterial growth, cessation of their reproduction and death. The combination of active substances in the drug reduces the likelihood of resistant forms of pathogenic microflora.

Sulfanilamides are rapidly distributed throughout the body, their therapeutic concentration is detected in the serum within 25 hours. The concentration of sulfonamides in the kidneys is higher, and in the skin, liver and lungs is lower than in blood plasma.

Trimethoprim is rapidly distributed throughout the body, its maximum concentration is reached 4 hours after administration. Concentrations of trimethoprim in the lungs, liver and kidneys are higher than in blood plasma.

Sulfanilamides and trimethoprim are excreted by the kidneys by glomerular filtration and tubular secretion. A small amount is metabolized in the liver and excreted in the bile.

APPLICATION
Method of application and dosage
The drug is administered orally with drinking water or food. The dose is 0.3-0.35 g per 10 kg of body weight 1-2 times a day.

For poultry and rabbits, the dose is 1 g of the drug per 3 liters of water, the course is 4-6 days. Depending on the clinical signs of the disease, the initial dose can be increased by 30-50%, and the course of treatment is extended by 2-3 days.

At pig and poultry farms, the drug is given in a group method with water or feed in the doses listed in the table.

*Kilograms to a Pounds conversion table

With the group method, the dose of the drug is dissolved in half the daily rate of water. Part of the water without the drug is given after drinking the medicinal solution.

Reservation
Goats are hypersensitive to sulfonamides, so they should be administered with extreme caution.

After the last application of the drug slaughter of calves, lambs, pigs, rabbits for meat is allowed in 4 days, poultry – in 2 days. Meat obtained before this date is disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.

Indication
Treatment of calves, lambs under 6 weeks of age, horses, pigs, rabbits, dogs, cats, poultry (chickens, turkeys, ducks, geese) in diseases of the gastrointestinal tract (gastritis, enteritis, dyspepsia), respiratory organs (sore throat, tracheitis, pharyngitis, bronchopneumonia, pleurisy), genitourinary system (postpartum sepsis, cystitis, urethritis, endometritis), postoperative complications, as well as mastitis, actinomycosis, erysipelas, dysentery, diplococci, enterotoxemia, eimeriosis, colibacteriosis, Escherichia coli, diseases, mycoplasmosis, salmonellosis.

Contraindication
Do not prescribe to animals with hypersensitivity to the active substances of the drug, liver and kidney dysfunction, ruminants with functionally formed pancreas. Do not use for the treatment of laying hens, the eggs of which are eaten by humans.

Storage conditions
In a dry, dark place, out of reach of children at a temperature of +8 to +25 ° C.

The ready solution to use within days, at storage in the refrigerator – within 3 days.

Expiration date
2 years.